i drifted from sunday to wednesday over a year and only noticed when i checked the log, i could be wrong
#dosing-titration 2025-09-03
Wednesday53 messages11 participantstimes are UTC
Highlights from this day
- kev_measures — small steps are better than big ones and the only reason people take big ones is impatience, ill dig out the number 18:31
- dark_for_ten_days — the ladder in the trials is a starting point, not a schedule you owe anyone, for what its worth 20:33
- back_from_away — appetite returning at the end of the week is extremely common and is not the dose failing 21:22
- amsterdam_aliquot — do you count from injection day or from when you actually felt it 22:55
sorry to jump in i hold for two months minimum before i decide a dose has stopped doing anything
small steps are better than big ones and the only reason people take big ones is impatience, ill dig out the number
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do you tell your prescriber you held or do you just hold
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
how do you decide between holding and stepping when both feel wrong
n of 1
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holding is not failing. most people here who lasted two years held at least one dose for months, ask me again in a month
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no trial for that
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two weeks is nothing
*week 19 not week 2
not advice
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update from 1 months ago: held at the same dose the whole time and still losing slowly
unrelated but if you are going up because the scale stalled for two weeks, wait. two weeks is noise
thats noise
how long did you hold at 1 before you moved up
New independent result logged — QSC, lot SG-1177, purity 99.2% (Medutest).
hold
too early imo
held for months
split dosing has no trial behind it. people here do it and report on it, thats all, anyway
does a missed week reset anything or do you just carry on
with a roughly seven day half-life you are near steady state after about five weeks at a dose
i went up too fast and im paying for it, do i drop back or ride it out
i escalate on symptoms. if the current dose is still doing something i stay on it
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the ladder in the trials is a starting point, not a schedule you owe anyone, for what its worth
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how do you tell a plateau from just being at your set point
the honest answer is that most of us are running protocols nobody has ever studied
nobody here can tell you what dose to be on and the ones who try get corrected
is week 15 too early to be thinking about the next step
if you are asking whether to go up, the fact you are asking usually means not yet
for the archive my titration ladder took 13 months to climb and i would do it slower again
whats the longest anyone has stayed on one dose
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the trials escalated on a fixed schedule because a trial has to. you are not a trial
what does the room think about jumping a rung to catch up
steady state is 5 weeks
plateau versus set point is not answerable in under six months of data, ill dig out the number
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mggo slower
appetite returning at the end of the week is extremely common and is not the dose failing
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anyone here split their weekly into two and would they do it again
do you escalate on the calendar or on how you feel
right so after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
coming back to this if it "stopped working after four days" that is almost never pharmacokinetics
came down from a treatment dose to maintenance over about three months and it was uneventful
end of week thing
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unrelated but my dose day has drifted 8 days later over 9 months, does it matter
thats normal
whats the smallest step anyone has managed between doses
[redacted at member request] · archive policy
do you count from injection day or from when you actually felt it
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the people who do best here are almost always the ones going slowest
if the current dose is still working, going up is spending headroom you might want later