#dosing-titration 2025-09-04

Thursday17 messages5 participantstimes are UTC

Highlights from this day

pharmac_pen — right so is week 34 too early to be thinking about the next step 15:19
sgp_subq — dose day drift is mostly harmless with a weekly compound, but pick a day and defend it 16:35
two_three_lifts — whats the smallest step anyone has managed between doses 16:39

i log dose, day, weight and one line about how the week felt. thats enough to make decisions on

Digest for the week of 2025-07-19 has been published.

thats noise

🤝2

the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, thats just me

i would hold

[edited]

anyone tracked whether a smaller more frequent dose changed their side effects

✅4

right so is week 34 too early to be thinking about the next step

wk 1-4    2.5mg
wk 5-8    5.0mg
wk 9-20   7.5mg   <- stayed here
wk 21-24  10.0mg  (no extra benefit for me)
wk 25+    7.5mg   (came back down)

i have been at 0.25 for 24 months and honestly i have stopped wanting to move

genuine question coming down from 2 to 10, how bad is the appetite rebound

hold

if you are going up because the scale stalled for two weeks, wait. two weeks is noise

dose day drift is mostly harmless with a weekly compound, but pick a day and defend it

Cited study

Effect of Continued Weekly Semaglutide vs Placebo on Weight Loss Maintenance (STEP 4)

JAMA · 2021

The withdrawal arm. This is the trial to read before you plan to stop.

😂1💀14

do you count from injection day or from when you actually felt it

whats the smallest step anyone has managed between doses

wk 1-4    2.5mg
wk 5-8    5.0mg
wk 9-20   7.5mg   <- stayed here
wk 21-24  10.0mg  (no extra benefit for me)
wk 25+    7.5mg   (came back down)

thats anecdote

if i hold at 2.5 indefinitely am i losing anything

steady state is 5 weeks