held for months
#dosing-titration 2025-09-05
Friday24 messages5 participantstimes are UTC
Highlights from this day
- gall_bladder_gav — unrelated but small steps are better than big ones and the only reason people take big ones is impatience, someone check my working 18:37
- two_four_ceiling — with a roughly seven day half-life you are near steady state after about five weeks at a dose 18:39
- two_four_ceiling — whats the smallest step anyone has managed between doses plateau versus set point is not answerable in under six months of data 18:41
- two_four_ceiling — appetite returning at the end of the week is extremely common and is not the dose failing 20:39
coming down from 10 to 0.25, how bad is the appetite rebound
unrelated but small steps are better than big ones and the only reason people take big ones is impatience, someone check my working
with a roughly seven day half-life you are near steady state after about five weeks at a dose
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whats the smallest step anyone has managed between doses
plateau versus set point is not answerable in under six months of data
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while im here if the current dose is still working, going up is spending headroom you might want later
thats noise
genuine question if you are going up because the scale stalled for two weeks, wait. two weeks is noise
[edited]whats your rule for when a side effect means hold rather than push
ok so the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
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i would hold
end of week thing
came down, no regrets
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two_four_ceilingwhile im here if the current dose is still working, going up is spending headroom you…
update from 12 months ago: held at the same dose the whole time and still losing slowly
i hold for two months minimum before i decide a dose has stopped doing anything
sorry to jump in the people who do best here are almost always the ones going slowest
if it "stopped working after four days" that is almost never pharmacokinetics
steady state is 5 weeks
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appetite returning at the end of the week is extremely common and is not the dose failing
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quick one how do you tell a plateau from just being at your set point
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pick a day and stick to it
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is there any actual reason to escalate every 4 weeks other than the trial did it
two weeks is nothing