two weeks is nothing
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#dosing-titration 2025-09-10
Wednesday53 messages11 participantstimes are UTC
Highlights from this day
- logrotate — appetite returning at the end of the week is extremely common and is not the dose failing if you are going up because the scale stalled for two weeks, wait. two weeks… 19:58
- lisbon_lot — if you are going up because the scale stalled for two weeks, wait. two weeks is noise, i think 19:59
- VialBot — Testing queue: 5 submissions open, 84 awaiting dispatch. 21:01
- VialBot — Reminder for mg_per_ml: dose day is today. Set 3 days ago. 21:50
- logrotate — anyone tracked whether a smaller more frequent dose changed their side effects 21:58
steady state is 5 weeks
appetite returning at the end of the week is extremely common and is not the dose failing
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
if you are going up because the scale stalled for two weeks, wait. two weeks is noise, i think
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whats a sensible maintenance dose after a year at treatment dose
i have been at 15 for 10 months and honestly i have stopped wanting to move
how long did you hold at 15 before you moved up
held for months
the people who do best here are almost always the ones going slowest
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
no trial for that
thats noise
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat, ill dig out the number
how much does the last dose still matter 8 days later
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
[edited]came down from a treatment dose to maintenance over about three months and it was uneventful, we shall see
half life is a week
the trials escalated on a fixed schedule because a trial has to. you are not a trial
thats anecdote
the ladder in the trials is a starting point, not a schedule you owe anyone
update from 5 months ago: held at the same dose the whole time and still losing slowly
coming down from 2.4 to 7.5, how bad is the appetite rebound
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
Testing queue: 5 submissions open, 84 awaiting dispatch.
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
do you tell your prescriber you held or do you just hold
go slower
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thats normal
if i hold at 1 indefinitely am i losing anything
[edited]how do you tell a plateau from just being at your set point
n of 1
too early imo
small steps are better than big ones and the only reason people take big ones is impatience
unrelated but is there a point where going up stops buying you anything
i escalate on symptoms. if the current dose is still doing something i stay on it
do you escalate on the calendar or on how you feel
came down, no regrets
pick a day and stick to it
Reminder for mg_per_ml: dose day is today. Set 3 days ago.
i would hold
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
if it "stopped working after four days" that is almost never pharmacokinetics
the honest answer is that most of us are running protocols nobody has ever studied
anyone tracked whether a smaller more frequent dose changed their side effects
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my dose day has drifted 9 days later over 13 months, does it matter
update question: did anyone who held for 23 months regret it
whats the smallest step anyone has managed between doses
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
stepping back down on purpose is a completely reasonable move and this channel should say so more often, for what its worth
end of week thing
i hold for two months minimum before i decide a dose has stopped doing anything
whats the longest anyone has stayed on one dose
how do you decide between holding and stepping when both feel wrong
holding is not failing. most people here who lasted two years held at least one dose for months