#dosing-titration 2025-09-12

Friday19 messages5 participantstimes are UTC

Highlights from this day

endotoxin_ed — follow up if i hold at 0.25 indefinitely am i losing anything 16:30
perth_pin — small steps are better than big ones and the only reason people take big ones is impatience 18:36
egfr_ed — i drifted from sunday to wednesday over a year and only noticed when i checked the log 19:06
egfr_ed — appetite returning at the end of the week is extremely common and is not the dose failing 19:08

i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else

while im here the trials escalated on a fixed schedule because a trial has to. you are not a trial

quick one my titration ladder took 1 months to climb and i would do it slower again

follow up if i hold at 0.25 indefinitely am i losing anything

📉5🧪18🎉1

after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice

pick a day and stick to it

thats normal

my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step

not advice

i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat

[edited]

whats a sensible maintenance dose after a year at treatment dose

end of week thing

small steps are better than big ones and the only reason people take big ones is impatience

⚠️8🙏1👀4

how do you decide between holding and stepping when both feel wrong

👍3🎉5

i drifted from sunday to wednesday over a year and only noticed when i checked the log

wk 1-4    2.5mg
wk 5-8    5.0mg
wk 9-20   7.5mg   <- stayed here
wk 21-24  10.0mg  (no extra benefit for me)
wk 25+    7.5mg   (came back down)

appetite returning at the end of the week is extremely common and is not the dose failing

😂8❤️11🙏4

thats noise

update from 26 months ago: held at the same dose the whole time and still losing slowly

whats the smallest step anyone has managed between doses