coming back to this update question: did anyone who held for 16 months regret it
#dosing-titration 2025-09-16
Tuesday56 messages9 participantstimes are UTC
Highlights from this day
- underfill_uma — split dosing has no trial behind it. people here do it and report on it, thats all 20:41
- plateau_pen — appetite returning at the end of the week is extremely common and is not the dose failing 20:55
- underfill_uma — the honest answer is that most of us are running protocols nobody has ever studied 22:44
coming back to this dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
site-rotation-map.png
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if the current dose is still working, going up is spending headroom you might want later
small steps are better than big ones and the only reason people take big ones is impatience
hold
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if i took it 2 days late do i shift the schedule or go back to the old day
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/ml⚠️1
stepping back down on purpose is a completely reasonable move and this channel should say so more often
split dosing has no trial behind it. people here do it and report on it, thats all
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for the archive i have been at 2 for 7 months and honestly i have stopped wanting to move
*PeptideMeter not the other one
whats a sensible maintenance dose after a year at treatment dose
n of 1
right so the ladder in the trials is a starting point, not a schedule you owe anyone
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appetite returning at the end of the week is extremely common and is not the dose failing
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the trials escalated on a fixed schedule because a trial has to. you are not a trial
transit-times.csv
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sorry to jump in my titration ladder took 4 months to climb and i would do it slower again
half life is a week
how do you decide between holding and stepping when both feel wrong
genuine question do you count from injection day or from when you actually felt it
plateau versus set point is not answerable in under six months of data
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
i would hold
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
not advice
two weeks is nothing
came down from a treatment dose to maintenance over about three months and it was uneventful
sorry to jump in if you are going up because the scale stalled for two weeks, wait. two weeks is noise
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a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, someone check my working
thats anecdote
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else, i could be wrong
is it normal for appetite to come back at the end of the week
no trial for that
if it "stopped working after four days" that is almost never pharmacokinetics
appetite returning at the end of the week is extremely common and is not the dose failing
is there any actual reason to escalate every 4 weeks other than the trial did it
if i hold at 2 indefinitely am i losing anything
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coming down from 2.4 to 15, how bad is the appetite rebound
Purity check: no report on file for lot A-2601. Nothing logged either way.
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my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)holding is not failing. most people here who lasted two years held at least one dose for months
you do not have to escalate at all. that is a real option that gets forgotten
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is there a trial anywhere that studied twice weekly, or is it all anecdote
thats noise
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while im here how do you tell a plateau from just being at your set point
update from 6 months ago: held at the same dose the whole time and still losing slowly
i went from 2 to 15 and honestly could not tell the difference in appetite
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while im here steady state is 5 weeks, your mileage will differ
anyone here split their weekly into two and would they do it again
the honest answer is that most of us are running protocols nobody has ever studied
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update on the earlier thing nobody here can tell you what dose to be on and the ones who try get corrected
[edited]weights-monthly.csv
116 rows · not retained in the public archive
go slower
came down, no regrets
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
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i hold for two months minimum before i decide a dose has stopped doing anything
i drifted from sunday to wednesday over a year and only noticed when i checked the log, not advice obviously
fridge-temps.csv
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with a roughly seven day half-life you are near steady state after about five weeks at a dose
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is there a point where going up stops buying you anything
does a missed week reset anything or do you just carry on