dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
#dosing-titration 2025-09-17
Wednesday26 messages8 participantstimes are UTC
Highlights from this day
- fake_tracking — while im here the trials escalated on a fixed schedule because a trial has to. you are not a trial, ill dig out the number 20:33
- per_mg_pete — the ladder in the trials is a starting point, not a schedule you owe anyone 21:02
- VialBot — New independent result logged — KP, lot H-2814, purity 98.6% (Medutest). 21:04
- per_mg_pete — i went from 15 to 5 and honestly could not tell the difference in appetite i hold for two months minimum before i decide a dose has stopped doing anything 21:10
- thursday_thea — my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step 21:35
slightly off topic but whats a sensible maintenance dose after a year at treatment dose
while im here the trials escalated on a fixed schedule because a trial has to. you are not a trial, ill dig out the number
thats normal
[edited]thats noise
i would hold
the ladder in the trials is a starting point, not a schedule you owe anyone
🙏10
quick one if the current dose is still working, going up is spending headroom you might want later
New independent result logged — KP, lot H-2814, purity 98.6% (Medutest).
i went from 15 to 5 and honestly could not tell the difference in appetite
i hold for two months minimum before i decide a dose has stopped doing anything
do you escalate on the calendar or on how you feel
whats the longest anyone has stayed on one dose
holding is not failing. most people here who lasted two years held at least one dose for months, someone check my working
two weeks is nothing
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)*week 20 not week 3
go slower
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
👀3✅18
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
hold
the honest answer is that most of us are running protocols nobody has ever studied, i think
too early imo
if you are asking whether to go up, the fact you are asking usually means not yet, i think
no trial for that
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i drifted from sunday to wednesday over a year and only noticed when i checked the log
sorry to jump in my titration ladder took 11 months to climb and i would do it slower again
🧪1