i hold for two months minimum before i decide a dose has stopped doing anything
#dosing-titration 2025-10-15
Wednesday22 messages6 participantstimes are UTC
Highlights from this day
- meniscus_mel — follow up is it normal for appetite to come back at the end of the week 17:57
- triple_ag_tom — whats the longest anyone has stayed on one dose 18:03
- assay_not_purity — i escalate on symptoms. if the current dose is still doing something i stay on it 18:40
- VialBot — Purity check: no report on file for lot F-1330. Nothing logged either way. 19:28
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
pick a day and stick to it
holding is not failing. most people here who lasted two years held at least one dose for months
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how do you decide between holding and stepping when both feel wrong
no trial for that
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
follow up is it normal for appetite to come back at the end of the week
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whats a sensible maintenance dose after a year at treatment dose
my dose day has drifted 3 days later over 1 months, does it matter
if it "stopped working after four days" that is almost never pharmacokinetics
whats the longest anyone has stayed on one dose
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came down, no regrets
[edited]thats normal
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update from 3 months ago: held at the same dose the whole time and still losing slowly
you do not have to escalate at all. that is a real option that gets forgotten
i escalate on symptoms. if the current dose is still doing something i stay on it
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i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
nobody here can tell you what dose to be on and the ones who try get corrected
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, ymmv
weights-monthly.csv
822 rows · not retained in the public archive
Purity check: no report on file for lot F-1330. Nothing logged either way.
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with a roughly seven day half-life you are near steady state after about five weeks at a dose
fridge-thermometer.png
800 × 800 · 223 KB · not retained in the public archive
thats anecdote