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#dosing-titration 2025-10-16

Thursday20 messages5 participantstimes are UTC
Highlights from this day
  • customs_owl — holding is not failing. most people here who lasted two years held at least one dose for months, not advice obviously if you are asking whether to go up, the fact you… 10:55
  • customs_owl — plateau versus set point is not answerable in under six months of data, thats just me i escalate on symptoms. if the current dose is still doing something i stay on it 10:57
  • verify_or_dont — with a roughly seven day half-life you are near steady state after about five weeks at a dose 13:53
TE

i log dose, day, weight and one line about how the week felt. thats enough to make decisions on

CO

if i took it 8 days late do i shift the schedule or go back to the old day

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CO

split dosing has no trial behind it. people here do it and report on it, thats all, not advice obviously

CO

holding is not failing. most people here who lasted two years held at least one dose for months, not advice obviously
if you are asking whether to go up, the fact you are asking usually means not yet

plateau versus set point is not answerable in under six months of data, thats just me
i escalate on symptoms. if the current dose is still doing something i stay on it

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TE

has anyone gone up and then straight back down and been glad they tried

T5

my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step

T5

small steps are better than big ones and the only reason people take big ones is impatience

T5

i went from 5 to 2.4 and honestly could not tell the difference in appetite

VO

i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else

VO

after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice

VO

i escalate on symptoms. if the current dose is still doing something i stay on it

with a roughly seven day half-life you are near steady state after about five weeks at a dose

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TE

the trials escalated on a fixed schedule because a trial has to. you are not a trial, i have it written down somewhere