vialroom

#dosing-titration 2025-10-23

Thursday20 messages5 participantstimes are UTC
Highlights from this day
  • logrotate — the ladder in the trials is a starting point, not a schedule you owe anyone 20:39
  • logrotate — anyone here split their weekly into two and would they do it again 20:51
  • cagri_curious — how do you tell a plateau from just being at your set point 21:56
LO

the ladder in the trials is a starting point, not a schedule you owe anyone

Cited study
Semaglutide vs Liraglutide for Weight Loss in Adults with Overweight or Obesity (STEP 8)
JAMA · 2022
Weekly against daily, head to head.
LO

right so i went from 2 to 1 and honestly could not tell the difference in appetite

anyone here split their weekly into two and would they do it again

[edited]
Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.
TO

while im here i hold for two months minimum before i decide a dose has stopped doing anything

peptidemeter-summary-a-2418.pdf
2 pages · 883 KB · not retained in the public archive
LO

unrelated but dose day drift is mostly harmless with a weekly compound, but pick a day and defend it

LO

do you count from injection day or from when you actually felt it

TO

the honest answer is that most of us are running protocols nobody has ever studied

while im here if you are going up because the scale stalled for two weeks, wait. two weeks is noise

[edited]
CC

two weeks is nothing

wk 1-4    0.25mg
wk 5-10   0.50mg   (held 2 extra weeks)
wk 11-14  1.00mg
wk 15-26  1.70mg   (held, long)
wk 27+    2.40mg
CC

the trials escalated on a fixed schedule because a trial has to. you are not a trial

i would hold

held for months

how do you tell a plateau from just being at your set point

💀63🎉17
NP

small steps are better than big ones and the only reason people take big ones is impatience

holding is not failing. most people here who lasted two years held at least one dose for months