genuine question is it normal for appetite to come back at the end of the week
with a roughly seven day half-life you are near steady state after about five weeks at a dose
#dosing-titration 2025-12-13
Saturday59 messages10 participantstimes are UTC
Highlights from this day
- sulphur_burp — whats your rule for when a side effect means hold rather than push 15:55
- sulphur_burp — holding is not failing. most people here who lasted two years held at least one dose for months 16:19
- chain_of_custody — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored 17:33
- chain_of_custody — is there any actual reason to escalate every 4 weeks other than the trial did it 17:42
you do not have to escalate at all. that is a real option that gets forgotten, still working it out
split dosing has no trial behind it. people here do it and report on it, thats all
right so i went from 0.5 to 5 and honestly could not tell the difference in appetite
came down from a treatment dose to maintenance over about three months and it was uneventful
coming back to this small steps are better than big ones and the only reason people take big ones is impatience
genuine question is there a trial anywhere that studied twice weekly, or is it all anecdote
*week 26 not week 5
do you tell your prescriber you held or do you just hold
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, your mileage will differ
whats your rule for when a side effect means hold rather than push
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how do you decide between holding and stepping when both feel wrong
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
the honest answer is that most of us are running protocols nobody has ever studied, someone check my working
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
holding is not failing. most people here who lasted two years held at least one dose for months
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my titration ladder took 21 months to climb and i would do it slower again
stepping back down on purpose is a completely reasonable move and this channel should say so more often
i drifted from sunday to wednesday over a year and only noticed when i checked the log, we shall see
does a missed week reset anything or do you just carry on
i would hold
too early imo
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
i hold for two months minimum before i decide a dose has stopped doing anything
whats the longest anyone has stayed on one dose
pick a day and stick to it
n of 1
for the archive nobody here can tell you what dose to be on and the ones who try get corrected
genuine question i escalate on symptoms. if the current dose is still doing something i stay on it
with a roughly seven day half-life you are near steady state after about five weeks at a dose
thats normal
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
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plateau versus set point is not answerable in under six months of data, anyway
came down, no regrets
is there any actual reason to escalate every 4 weeks other than the trial did it
[edited]| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
do you escalate on the calendar or on how you feel
half life is a week
held for months
two weeks is nothing
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
is week 8 too early to be thinking about the next step
18:34quiet.hours pinned a message to this channel
if the current dose is still working, going up is spending headroom you might want later
the ladder in the trials is a starting point, not a schedule you owe anyone
no trial for that
the trials escalated on a fixed schedule because a trial has to. you are not a trial
steady state is 5 weeks
end of week thing
if you are asking whether to go up, the fact you are asking usually means not yet
the people who do best here are almost always the ones going slowest, ill dig out the number
my dose day has drifted 6 days later over 22 months, does it matter
hold
go slower
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i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
if i hold at 15 indefinitely am i losing anything
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not advice
coming back to this i went up too fast and im paying for it, do i drop back or ride it out
update from 21 months ago: held at the same dose the whole time and still losing slowly
thats anecdote