vialroom

#dosing-titration 2025-12-10

Wednesday15 messages5 participantstimes are UTC
Highlights from this day
  • tarpit_tam — if you are asking whether to go up, the fact you are asking usually means not yet 17:55
  • impersonator_ip — if it "stopped working after four days" that is almost never pharmacokinetics 19:19
  • impersonator_ip — right so coming down from 7.5 to 2.4, how bad is the appetite rebound 19:58
  • meniscus_mel — nobody here can tell you what dose to be on and the ones who try get corrected, we shall see 22:28
TT

if you are asking whether to go up, the fact you are asking usually means not yet

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split dosing has no trial behind it. people here do it and report on it, thats all

is there a point where going up stops buying you anything

DE

dose day drift is mostly harmless with a weekly compound, but pick a day and defend it

[edited]

i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat, your mileage will differ

DE

is it normal for appetite to come back at the end of the week

TT

i would hold

Cited study
Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1)
New England Journal of Medicine · 2021
68 weeks, semaglutide 2.4mg weekly against placebo, with lifestyle intervention in both arms.
II

if it "stopped working after four days" that is almost never pharmacokinetics

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II

right so coming down from 7.5 to 2.4, how bad is the appetite rebound

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II

while im here is there a trial anywhere that studied twice weekly, or is it all anecdote

DE

ok so if you are going up because the scale stalled for two weeks, wait. two weeks is noise

U-100 syringe: 1 unit = 0.01 ml
  10u = 0.10 ml
  25u = 0.25 ml
  50u = 0.50 ml
 100u = 1.00 ml
mg drawn = ml drawn x mg/ml

whats the longest anyone has stayed on one dose

VB

Batch lookup A-2418: 6 independent reports on file, earliest 2025-05-24.

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MM

the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, take that with a pinch of salt

MM

nobody here can tell you what dose to be on and the ones who try get corrected, we shall see

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