whats the longest anyone has stayed on one dose
#dosing-titration 2025-12-09
Tuesday54 messages12 participantstimes are UTC
Highlights from this day
- quiet_head_qi — i have been at 0.25 for 9 months and honestly i have stopped wanting to move 21:04
- is_this_forever — coming back to this update from 20 months ago: held at the same dose the whole time and still losing slowly 21:18
- seven_five_sweet — appetite returning at the end of the week is extremely common and is not the dose failing 21:30
- taper_tess — how do you decide between holding and stepping when both feel wrong 21:54
- taper_tess — is there any actual reason to escalate every 4 weeks other than the trial did it 22:27
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
split dosing has no trial behind it. people here do it and report on it, thats all
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
go slower
whats a sensible maintenance dose after a year at treatment dose
end of week thing
too early imo
you do not have to escalate at all. that is a real option that gets forgotten
i have been at 0.25 for 9 months and honestly i have stopped wanting to move
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thats normal
whats the smallest step anyone has managed between doses
stepping back down on purpose is a completely reasonable move and this channel should say so more often
whats your rule for when a side effect means hold rather than push
coming back to this update from 20 months ago: held at the same dose the whole time and still losing slowly
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what does the room think about jumping a rung to catch up
right so the honest answer is that most of us are running protocols nobody has ever studied, your mileage will differ
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
appetite returning at the end of the week is extremely common and is not the dose failing
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does a missed week reset anything or do you just carry on
i escalate on symptoms. if the current dose is still doing something i stay on it
while im here how long did you hold at 12 before you moved up
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
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half life is a week
came down, no regrets
how do you decide between holding and stepping when both feel wrong
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Testing queue: 2 submissions open, 38 awaiting dispatch.
update on the earlier thing if it "stopped working after four days" that is almost never pharmacokinetics
*VendorInvestigate not the other one
steady state is 5 weeks
Digest for the week of 2025-05-13 has been published.
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the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
nobody here can tell you what dose to be on and the ones who try get corrected
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/mlif the current dose is still working, going up is spending headroom you might want later
thats anecdote
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/mlis there any actual reason to escalate every 4 weeks other than the trial did it
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/mli hold for two months minimum before i decide a dose has stopped doing anything
if you are asking whether to go up, the fact you are asking usually means not yet
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two weeks is nothing
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plateau versus set point is not answerable in under six months of data
right so i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
small steps are better than big ones and the only reason people take big ones is impatience
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no trial for that
my titration ladder took 21 months to climb and i would do it slower again
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dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, happy to be corrected
Reminder set. I will post here in 7 days.
the trials escalated on a fixed schedule because a trial has to. you are not a trial
how do you tell a plateau from just being at your set point
update question: did anyone who held for 1 months regret it
n of 1
hold
my dose day has drifted 7 days later over 5 months, does it matter
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my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
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is week 6 too early to be thinking about the next step