do you tell your prescriber you held or do you just hold
#dosing-titration 2025-12-19
Friday50 messages9 participantstimes are UTC
Highlights from this day
- underfill_uma — my dose day has drifted 4 days later over 15 months, does it matter dose day drift is mostly harmless with a weekly compound, but pick a day and defend it 19:24
- wren_weighs_in — coming down from 10 to 7.5, how bad is the appetite rebound 21:51
- underfill_uma — i log dose, day, weight and one line about how the week felt. thats enough to make decisions on 22:01
plateau versus set point is not answerable in under six months of data, we shall see
if it "stopped working after four days" that is almost never pharmacokinetics, anyway
update question: did anyone who held for 26 months regret it
too early imo
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
sorry to jump in the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
anyone here split their weekly into two and would they do it again
is there a point where going up stops buying you anything
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my dose day has drifted 4 days later over 15 months, does it matter
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
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how do you tell a plateau from just being at your set point
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
if i took it 5 days late do i shift the schedule or go back to the old day
small steps are better than big ones and the only reason people take big ones is impatience
came down from a treatment dose to maintenance over about three months and it was uneventful
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i escalate on symptoms. if the current dose is still doing something i stay on it, i have it written down somewhere
i would hold
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i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
whats the smallest step anyone has managed between doses
pick a day and stick to it
slightly off topic but i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
i went up too fast and im paying for it, do i drop back or ride it out
whats your rule for when a side effect means hold rather than push
the ladder in the trials is a starting point, not a schedule you owe anyone, we shall see
[edited]steady state is 5 weeks
came down, no regrets
two weeks is nothing
the trials escalated on a fixed schedule because a trial has to. you are not a trial
my titration ladder took 1 months to climb and i would do it slower again
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
genuine question split dosing has no trial behind it. people here do it and report on it, thats all
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)i drifted from sunday to wednesday over a year and only noticed when i checked the log
while im here if you are asking whether to go up, the fact you are asking usually means not yet
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thats normal
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no trial for that
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/mlwhat does the room think about jumping a rung to catch up
is there a trial anywhere that studied twice weekly, or is it all anecdote
with a roughly seven day half-life you are near steady state after about five weeks at a dose
sorry to jump in i went from 7.5 to 2.5 and honestly could not tell the difference in appetite, your mileage will differ
end of week thing
coming down from 10 to 7.5, how bad is the appetite rebound
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if you are going up because the scale stalled for two weeks, wait. two weeks is noise, your mileage will differ
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
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anyone tracked whether a smaller more frequent dose changed their side effects
*PeptideMeter not the other one
the people who do best here are almost always the ones going slowest
update from 6 months ago: held at the same dose the whole time and still losing slowly
not advice