i would hold
#dosing-titration 2025-12-18
Thursday47 messages9 participantstimes are UTC
Highlights from this day
- cold_chain_cmdr — coming down from 15 to 12, how bad is the appetite rebound 18:24
- rotate_the_site — anyone here split their weekly into two and would they do it again 19:07
- site_itch — i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat 19:31
- reed_reta — holding is not failing. most people here who lasted two years held at least one dose for months 21:06
if it "stopped working after four days" that is almost never pharmacokinetics
the ladder in the trials is a starting point, not a schedule you owe anyone
how long did you hold at 1 before you moved up
is there a trial anywhere that studied twice weekly, or is it all anecdote
update from 13 months ago: held at the same dose the whole time and still losing slowly
[edited]is there a point where going up stops buying you anything
coming down from 15 to 12, how bad is the appetite rebound
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if the current dose is still working, going up is spending headroom you might want later
small steps are better than big ones and the only reason people take big ones is impatience
i went from 2.5 to 5 and honestly could not tell the difference in appetite
two weeks is nothing
has anyone gone up and then straight back down and been glad they tried
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
for the archive nobody here can tell you what dose to be on and the ones who try get corrected
unrelated but update question: did anyone who held for 25 months regret it
thats normal
you do not have to escalate at all. that is a real option that gets forgotten
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)anyone here split their weekly into two and would they do it again
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half life is a week
too early imo
no trial for that
how do you tell a plateau from just being at your set point
held for months
if you are asking whether to go up, the fact you are asking usually means not yet, i think
whats the longest anyone has stayed on one dose
you do not have to escalate at all. that is a real option that gets forgotten
not advice
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
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my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
if i hold at 1 indefinitely am i losing anything
the trials escalated on a fixed schedule because a trial has to. you are not a trial
is it normal for appetite to come back at the end of the week
[edited]pick a day and stick to it
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steady state is 5 weeks
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came down from a treatment dose to maintenance over about three months and it was uneventful, not advice obviously
the trials escalated on a fixed schedule because a trial has to. you are not a trial
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the honest answer is that most of us are running protocols nobody has ever studied
20:51chlorhex pinned a message
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, ill dig out the number
do you escalate on the calendar or on how you feel
thats noise
whats your rule for when a side effect means hold rather than push
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
whats the smallest step anyone has managed between doses
unrelated but came down, no regrets
the people who do best here are almost always the ones going slowest
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holding is not failing. most people here who lasted two years held at least one dose for months
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with a roughly seven day half-life you are near steady state after about five weeks at a dose
hold
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