the people who do best here are almost always the ones going slowest
#dosing-titration 2025-12-22
Monday23 messages5 participantstimes are UTC
Highlights from this day
- seven_five_sweet — is there a trial anywhere that studied twice weekly, or is it all anecdote 19:31
- seven_five_sweet — slightly off topic but with a roughly seven day half-life you are near steady state after about five weeks at a dose 20:07
- meniscus_mel — i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, for what its worth 20:08
- mid_week_mo — how much does the last dose still matter 8 days later 21:28
whats the smallest step anyone has managed between doses
anyone tracked whether a smaller more frequent dose changed their side effects
update question: did anyone who held for 17 months regret it
if the current dose is still working, going up is spending headroom you might want later
small steps are better than big ones and the only reason people take big ones is impatience
is there a trial anywhere that studied twice weekly, or is it all anecdote
🤝4👀1
is there any actual reason to escalate every 4 weeks other than the trial did it
slightly off topic but update from 16 months ago: held at the same dose the whole time and still losing slowly
the trials escalated on a fixed schedule because a trial has to. you are not a trial
hard_stop_halslightly off topic but update from 16 months ago: held at the same dose the whole time…
slightly off topic but with a roughly seven day half-life you are near steady state after about five weeks at a dose
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, for what its worth
💀10
no trial for that
end of week thing
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
thats noise
if it "stopped working after four days" that is almost never pharmacokinetics, n of 1 obviously
nobody here can tell you what dose to be on and the ones who try get corrected
my titration ladder took 14 months to climb and i would do it slower again
how much does the last dose still matter 8 days later
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)is week 31 too early to be thinking about the next step
half life is a week
how long did you hold at 1.7 before you moved up
the honest answer is that most of us are running protocols nobody has ever studied, take that with a pinch of salt