the people who do best here are almost always the ones going slowest
#dosing-titration 2026-01-26
Monday30 messages8 participantstimes are UTC
Highlights from this day
- month_six_me — i hold for two months minimum before i decide a dose has stopped doing anything, i could be wrong 13:41
- batch_bandit — the trials escalated on a fixed schedule because a trial has to. you are not a trial 15:04
- triple_ag_tom — appetite returning at the end of the week is extremely common and is not the dose failing 17:49
- batch_bandit — came down from a treatment dose to maintenance over about three months and it was uneventful, ask me again in a month 18:15
i hold for two months minimum before i decide a dose has stopped doing anything, i could be wrong
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stepping back down on purpose is a completely reasonable move and this channel should say so more often
i went from 1.7 to 2 and honestly could not tell the difference in appetite
if the current dose is still working, going up is spending headroom you might want later
if i hold at 5 indefinitely am i losing anything
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, n of 1 obviously
how do you decide between holding and stepping when both feel wrong
Purity check: no report on file for lot E-2205. Nothing logged either way.
the trials escalated on a fixed schedule because a trial has to. you are not a trial
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
whats a sensible maintenance dose after a year at treatment dose
coming down from 0.5 to 12, how bad is the appetite rebound
whats the longest anyone has stayed on one dose
the honest answer is that most of us are running protocols nobody has ever studied
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
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if you are asking whether to go up, the fact you are asking usually means not yet
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held for months
steady state is 5 weeks
my titration ladder took 2 months to climb and i would do it slower again
holding is not failing. most people here who lasted two years held at least one dose for months
i drifted from sunday to wednesday over a year and only noticed when i checked the log
follow up a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
ok so you do not have to escalate at all. that is a real option that gets forgotten
update from 9 months ago: held at the same dose the whole time and still losing slowly
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appetite returning at the end of the week is extremely common and is not the dose failing
i have been at 15 for 16 months and honestly i have stopped wanting to move
slightly off topic but i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, n of 1 obviously
thats anecdote
came down from a treatment dose to maintenance over about three months and it was uneventful, ask me again in a month
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if you are going up because the scale stalled for two weeks, wait. two weeks is noise, for what its worth
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