too early imo
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
#dosing-titration 2026-01-27
Tuesday61 messages15 participantstimes are UTC
Highlights from this day
- VialBot — Archive lookup: amsterdam_aliquot first appears in this channel on 2025-03-09. 19:12
- protein_floor — my dose day has drifted 9 days later over 8 months, does it matter 21:02
- retention_time — you do not have to escalate at all. that is a real option that gets forgotten 21:32
- slow.taper — how do you decide between holding and stepping when both feel wrong 22:08
half life is a week
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
18:08quiet.hours pinned a message to this channel
with a roughly seven day half-life you are near steady state after about five weeks at a dose
holding is not failing. most people here who lasted two years held at least one dose for months
if i hold at 2 indefinitely am i losing anything
not advice
update on the earlier thing how long did you hold at 0.25 before you moved up
anyone here split their weekly into two and would they do it again
medutest-report-a-2418.pdf
3 pages · 203 KB · not retained in the public archive
go slower
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
anyone tracked whether a smaller more frequent dose changed their side effects
*Medutest not the other one
no trial for that
i would hold
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
coming down from 2 to 7.5, how bad is the appetite rebound
appetite returning at the end of the week is extremely common and is not the dose failing
Archive lookup: amsterdam_aliquot first appears in this channel on 2025-03-09.
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i escalate on symptoms. if the current dose is still doing something i stay on it
held for months
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgi log dose, day, weight and one line about how the week felt. thats enough to make decisions on
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if you are going up because the scale stalled for two weeks, wait. two weeks is noise, i think
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two weeks is nothing
follow up split dosing has no trial behind it. people here do it and report on it, thats all
i went up too fast and im paying for it, do i drop back or ride it out
if the current dose is still working, going up is spending headroom you might want later, we shall see
[edited]dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
thats noise
slightly off topic but the ladder in the trials is a starting point, not a schedule you owe anyone
update question: did anyone who held for 11 months regret it
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came down, no regrets
i went from 0.25 to 5 and honestly could not tell the difference in appetite
n of 1
i drifted from sunday to wednesday over a year and only noticed when i checked the log
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
pick a day and stick to it
right so stepping back down on purpose is a completely reasonable move and this channel should say so more often
thats anecdote
end of week thing
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does a missed week reset anything or do you just carry on
hold
while im here is there a point where going up stops buying you anything
my dose day has drifted 9 days later over 8 months, does it matter
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is there a trial anywhere that studied twice weekly, or is it all anecdote
do you tell your prescriber you held or do you just hold
nobody here can tell you what dose to be on and the ones who try get corrected
i hold for two months minimum before i decide a dose has stopped doing anything
you do not have to escalate at all. that is a real option that gets forgotten
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small steps are better than big ones and the only reason people take big ones is impatience
steady state is 5 weeks
plateau versus set point is not answerable in under six months of data
has anyone gone up and then straight back down and been glad they tried
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how much does the last dose still matter 7 days later
*VendorInvestigate not the other one
came down from a treatment dose to maintenance over about three months and it was uneventful
what does the room think about jumping a rung to catch up
whats the longest anyone has stayed on one dose
update from 18 months ago: held at the same dose the whole time and still losing slowly, happy to be corrected
how do you decide between holding and stepping when both feel wrong
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