#dosing-titration 2026-02-06

Friday16 messages5 participantstimes are UTC

Highlights from this day

first_month_fi — i went from 2.4 to 5 and honestly could not tell the difference in appetite 14:52
first_month_fi — sorry to jump in the ladder in the trials is a starting point, not a schedule you owe anyone 14:58
thirty_one_g — update on the earlier thing split dosing has no trial behind it. people here do it and report on it, thats all 15:38
thirty_one_g — my dose day has drifted 6 days later over 15 months, does it matter 18:06
homa_ir_hugo — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, i think 19:11

i went from 2.4 to 5 and honestly could not tell the difference in appetite

🤝1🔥7👀14

held for months

sorry to jump in the ladder in the trials is a starting point, not a schedule you owe anyone

update on the earlier thing split dosing has no trial behind it. people here do it and report on it, thats all

👀7📉11🙏8

the honest answer is that most of us are running protocols nobody has ever studied

is there a trial anywhere that studied twice weekly, or is it all anecdote

pick a day and stick to it

the people who do best here are almost always the ones going slowest

my dose day has drifted 6 days later over 15 months, does it matter

✅3😂1

i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat

after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, i think

😂4🙏14🎉12

i have been at 1 for 12 months and honestly i have stopped wanting to move

if it "stopped working after four days" that is almost never pharmacokinetics

hold

is there any actual reason to escalate every 4 weeks other than the trial did it

update question: did anyone who held for 24 months regret it

[edited]