split dosing has no trial behind it. people here do it and report on it, thats all, someone check my working
#dosing-titration 2026-02-05
Thursday26 messages7 participantstimes are UTC
Highlights from this day
- zoya_zeros — i hold for two months minimum before i decide a dose has stopped doing anything 22:15
- dana_titrates — genuine question with a roughly seven day half-life you are near steady state after about five weeks at a dose 22:26
- VialBot — Purity check: no report on file for lot A-2601. Nothing logged either way. 23:05
- zoya_zeros — i went from 15 to 0.25 and honestly could not tell the difference in appetite 23:09
- zoya_zeros — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 23:33
i escalate on symptoms. if the current dose is still doing something i stay on it
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
*that should say weekly
you do not have to escalate at all. that is a real option that gets forgotten
half life is a week
whats your rule for when a side effect means hold rather than push
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat, still working it out
*week 22 not week 4
anyone tracked whether a smaller more frequent dose changed their side effects
i hold for two months minimum before i decide a dose has stopped doing anything
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n of 1
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plateau versus set point is not answerable in under six months of data
genuine question with a roughly seven day half-life you are near steady state after about five weeks at a dose
weights-monthly.csv
752 rows · not retained in the public archive
came down, no regrets
the trials escalated on a fixed schedule because a trial has to. you are not a trial
i drifted from sunday to wednesday over a year and only noticed when i checked the log
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
the ladder in the trials is a starting point, not a schedule you owe anyone
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if the current dose is still working, going up is spending headroom you might want later, i could be wrong
Purity check: no report on file for lot A-2601. Nothing logged either way.
too early imo
thats normal
i went from 15 to 0.25 and honestly could not tell the difference in appetite
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after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
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if it "stopped working after four days" that is almost never pharmacokinetics