#dosing-titration 2026-02-02

Monday18 messages5 participantstimes are UTC

Highlights from this day

nhs_pathway_nell — plateau versus set point is not answerable in under six months of data 01:48
nhs_pathway_nell — came down from a treatment dose to maintenance over about three months and it was uneventful, happy to be corrected 01:49
thursday_thea — sorry to jump in appetite returning at the end of the week is extremely common and is not the dose failing, from memory 02:52
nhs_pathway_nell — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, still working it out 02:59
nhs_pathway_nell — i have been at 2 for 10 months and honestly i have stopped wanting to move after a gap of more than about three weeks i restart one rung lower. thats my own rule, not… 03:04

gip_glp_gil 00:47

my titration ladder took 8 months to climb and i would do it slower again

hair_month_four 00:53

if you are asking whether to go up, the fact you are asking usually means not yet

seven_five_sweet 00:55

two weeks is nothing

😂16

gip_glp_gil 00:56

my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step

seven_five_sweet 01:37

if it "stopped working after four days" that is almost never pharmacokinetics

hold

nhs_pathway_nell 01:45

whats the smallest step anyone has managed between doses

plateau versus set point is not answerable in under six months of data

📉5🔥16

came down from a treatment dose to maintenance over about three months and it was uneventful, happy to be corrected

👍1

thursday_thea 01:51

if i hold at 7.5 indefinitely am i losing anything

seven_five_sweet 01:56

unrelated but is there a trial anywhere that studied twice weekly, or is it all anecdote

thursday_thea 02:01

has anyone gone up and then straight back down and been glad they tried

seven_five_sweet 02:16

sorry to jump in the honest answer is that most of us are running protocols nobody has ever studied

gip_glp_gil 02:19

nobody here can tell you what dose to be on and the ones who try get corrected

[edited]

gip_glp_gil 02:50

you do not have to escalate at all. that is a real option that gets forgotten

thursday_thea 02:52

sorry to jump in appetite returning at the end of the week is extremely common and is not the dose failing, from memory

nhs_pathway_nell 02:59

after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, still working it out

gip_glp_gil you do not have to escalate at all. that is a real option that gets forgotten

nhs_pathway_nell 03:04

i have been at 2 for 10 months and honestly i have stopped wanting to move
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice