thats normal
#dosing-titration 2026-03-03
Tuesday44 messages8 participantstimes are UTC
Highlights from this day
- cold_chain_cmdr — my dose day has drifted 8 days later over 17 months, does it matter 14:32
- protein_floor — i drifted from sunday to wednesday over a year and only noticed when i checked the log 15:22
- septum_sal — split dosing has no trial behind it. people here do it and report on it, thats all, thats just me the ladder in the trials is a starting point, not a schedule you owe… 16:19
is it normal for appetite to come back at the end of the week
how do you decide between holding and stepping when both feel wrong
thats noise
my dose day has drifted 8 days later over 17 months, does it matter
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgfor the archive nobody here can tell you what dose to be on and the ones who try get corrected
with a roughly seven day half-life you are near steady state after about five weeks at a dose
is there any actual reason to escalate every 4 weeks other than the trial did it
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
holding is not failing. most people here who lasted two years held at least one dose for months
anyone tracked whether a smaller more frequent dose changed their side effects
do you tell your prescriber you held or do you just hold
came down, no regrets
i drifted from sunday to wednesday over a year and only noticed when i checked the log
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hold
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
whats the longest anyone has stayed on one dose
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
if the current dose is still working, going up is spending headroom you might want later
how much does the last dose still matter 2 days later
whats your rule for when a side effect means hold rather than push
split dosing has no trial behind it. people here do it and report on it, thats all, thats just me
the ladder in the trials is a starting point, not a schedule you owe anyone
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is there a point where going up stops buying you anything
genuine question my titration ladder took 21 months to climb and i would do it slower again
came down from a treatment dose to maintenance over about three months and it was uneventful
i went from 12 to 1 and honestly could not tell the difference in appetite
pick a day and stick to it
slightly off topic but i have been at 15 for 25 months and honestly i have stopped wanting to move
if i took it 7 days late do i shift the schedule or go back to the old day
too early imo
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do you escalate on the calendar or on how you feel
update from 9 months ago: held at the same dose the whole time and still losing slowly
coming down from 2 to 0.25, how bad is the appetite rebound
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unrelated but has anyone gone up and then straight back down and been glad they tried
[edited]the ladder in the trials is a starting point, not a schedule you owe anyone
does a missed week reset anything or do you just carry on
two weeks is nothing
you do not have to escalate at all. that is a real option that gets forgotten
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coming back to this i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
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plateau versus set point is not answerable in under six months of data
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
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after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, i have it written down somewhere
genuine question stepping back down on purpose is a completely reasonable move and this channel should say so more often
small steps are better than big ones and the only reason people take big ones is impatience
how do you tell a plateau from just being at your set point