thats noise
#dosing-titration 2026-03-16
Monday52 messages10 participantstimes are UTC
Highlights from this day
half life is a week
thats anecdote
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*that should say weekly
do you tell your prescriber you held or do you just hold
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
split dosing has no trial behind it. people here do it and report on it, thats all
two weeks is nothing
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is there a point where going up stops buying you anything
pick a day and stick to it
has anyone gone up and then straight back down and been glad they tried
if i took it 2 days late do i shift the schedule or go back to the old day
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not advice
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n of 1
21:31quiet.hours pinned a message to this channel
appetite returning at the end of the week is extremely common and is not the dose failing, n of 1 obviously
my titration ladder took 21 months to climb and i would do it slower again
do you count from injection day or from when you actually felt it
whats the longest anyone has stayed on one dose
the trials escalated on a fixed schedule because a trial has to. you are not a trial
i would hold
[edited]after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
whats the smallest step anyone has managed between doses
held for months
the honest answer is that most of us are running protocols nobody has ever studied
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is week 23 too early to be thinking about the next step
update on the earlier thing dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, take that with a pinch of salt
whats your rule for when a side effect means hold rather than push
update question: did anyone who held for 3 months regret it
if i hold at 5 indefinitely am i losing anything
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how do you tell a plateau from just being at your set point
anyone here split their weekly into two and would they do it again
go slower
end of week thing
stepping back down on purpose is a completely reasonable move and this channel should say so more often, i have it written down somewhere
sorry to jump in how long did you hold at 15 before you moved up
you do not have to escalate at all. that is a real option that gets forgotten, n of 1 obviously
too early imo
hold
the people who do best here are almost always the ones going slowest
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
nobody here can tell you what dose to be on and the ones who try get corrected
the trials escalated on a fixed schedule because a trial has to. you are not a trial
my dose day has drifted 4 days later over 13 months, does it matter
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if you are asking whether to go up, the fact you are asking usually means not yet
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for the archive is there a trial anywhere that studied twice weekly, or is it all anecdote
with a roughly seven day half-life you are near steady state after about five weeks at a dose
thats normal
anyone tracked whether a smaller more frequent dose changed their side effects
for the archive i hold for two months minimum before i decide a dose has stopped doing anything
*VendorInvestigate not the other one
how do you decide between holding and stepping when both feel wrong
no trial for that