i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
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#dosing-titration 2026-03-15
Sunday58 messages14 participantstimes are UTC
Highlights from this day
- ghent_gradient — i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat 14:05
- factory_direct_fi — the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess 15:13
- declared_value — is there any actual reason to escalate every 4 weeks other than the trial did it if you are asking whether to go up, the fact you are asking usually means not yet 15:33
- gip_glp_gil — if i hold at 12 indefinitely am i losing anything 18:23
- still_here_2024 — is it normal for appetite to come back at the end of the week 20:43
i hold for two months minimum before i decide a dose has stopped doing anything
the people who do best here are almost always the ones going slowest
quick one a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, ill dig out the number
slightly off topic but you do not have to escalate at all. that is a real option that gets forgotten
if you are asking whether to go up, the fact you are asking usually means not yet
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
what does the room think about jumping a rung to catch up
not advice
coming back to this dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, from memory
does a missed week reset anything or do you just carry on
if i took it 2 days late do i shift the schedule or go back to the old day
i escalate on symptoms. if the current dose is still doing something i stay on it
small steps are better than big ones and the only reason people take big ones is impatience
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i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
end of week thing
two weeks is nothing
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
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how long did you hold at 0.5 before you moved up
i would hold
half life is a week
do you escalate on the calendar or on how you feel
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)is there any actual reason to escalate every 4 weeks other than the trial did it
if you are asking whether to go up, the fact you are asking usually means not yet
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the people who do best here are almost always the ones going slowest
whats the smallest step anyone has managed between doses
came down, no regrets
Archive lookup: sasha_stacks first appears in this channel on 2025-09-29.
holding is not failing. most people here who lasted two years held at least one dose for months
i went from 0.5 to 0.25 and honestly could not tell the difference in appetite, ask me again in a month
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
hold
the trials escalated on a fixed schedule because a trial has to. you are not a trial
steady state is 5 weeks
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how much does the last dose still matter 4 days later
no trial for that
thats anecdote
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whats a sensible maintenance dose after a year at treatment dose
is there a point where going up stops buying you anything
sorry to jump in coming down from 5 to 15, how bad is the appetite rebound
sorry to jump in plateau versus set point is not answerable in under six months of data
unrelated but if the current dose is still working, going up is spending headroom you might want later
n of 1
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do you tell your prescriber you held or do you just hold
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
with a roughly seven day half-life you are near steady state after about five weeks at a dose
[edited]came down from a treatment dose to maintenance over about three months and it was uneventful
while im here my dose day has drifted 6 days later over 4 months, does it matter
nobody here can tell you what dose to be on and the ones who try get corrected
i hold for two months minimum before i decide a dose has stopped doing anything
if i hold at 12 indefinitely am i losing anything
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how do you tell a plateau from just being at your set point
i have been at 0.5 for 11 months and honestly i have stopped wanting to move
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i drifted from sunday to wednesday over a year and only noticed when i checked the log
go slower
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
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stepping back down on purpose is a completely reasonable move and this channel should say so more often
if it "stopped working after four days" that is almost never pharmacokinetics
thats normal
the honest answer is that most of us are running protocols nobody has ever studied
update on the earlier thing appetite returning at the end of the week is extremely common and is not the dose failing
is it normal for appetite to come back at the end of the week
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whats your rule for when a side effect means hold rather than push