while im here i went from 1.7 to 2.4 and honestly could not tell the difference in appetite
#dosing-titration 2026-03-25
Wednesday26 messages9 participantstimes are UTC
Highlights from this day
- baseline_drift — i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, i have it written down somewhere 10:13
- seven_five_sweet — if you are asking whether to go up, the fact you are asking usually means not yet 11:31
- net_peptide — i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat 11:33
- elm_escalates — dose day drift is mostly harmless with a weekly compound, but pick a day and defend it 12:45
two weeks is nothing
ok so my titration ladder took 11 months to climb and i would do it slower again
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i drifted from sunday to wednesday over a year and only noticed when i checked the log
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, i have it written down somewhere
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thats noise
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the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgmy dose day has drifted 4 days later over 2 months, does it matter
not advice
sorry to jump in if i hold at 0.5 indefinitely am i losing anything
is there a point where going up stops buying you anything
came down from a treatment dose to maintenance over about three months and it was uneventful
stepping back down on purpose is a completely reasonable move and this channel should say so more often
if you are asking whether to go up, the fact you are asking usually means not yet
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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if you are going up because the scale stalled for two weeks, wait. two weeks is noise
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
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anyone tracked whether a smaller more frequent dose changed their side effects
split dosing has no trial behind it. people here do it and report on it, thats all
thats anecdote
the ladder in the trials is a starting point, not a schedule you owe anyone, happy to be corrected
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
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i would hold
too early imo
[edited]n of 1
held for months
how do you decide between holding and stepping when both feel wrong