thats noise
#dosing-titration 2026-05-18
Monday21 messages6 participantstimes are UTC
Highlights from this day
- escalation_anxiety — if you are going up because the scale stalled for two weeks, wait. two weeks is noise 16:20
- typosquat_tay — i drifted from sunday to wednesday over a year and only noticed when i checked the log 17:23
- typosquat_tay — dose day drift is mostly harmless with a weekly compound, but pick a day and defend it 17:30
- stack_sceptic — unrelated but do you count from injection day or from when you actually felt it 17:32
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
is week 5 too early to be thinking about the next step
follow up update from 15 months ago: held at the same dose the whole time and still losing slowly
update from 11 months ago: held at the same dose the whole time and still losing slowly
is it normal for appetite to come back at the end of the week
if i took it 3 days late do i shift the schedule or go back to the old day
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, anyway
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whats your rule for when a side effect means hold rather than push
nobody here can tell you what dose to be on and the ones who try get corrected
appetite returning at the end of the week is extremely common and is not the dose failing
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i drifted from sunday to wednesday over a year and only noticed when i checked the log
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small steps are better than big ones and the only reason people take big ones is impatience
i went from 0.25 to 12 and honestly could not tell the difference in appetite
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
came down, no regrets
unrelated but do you count from injection day or from when you actually felt it
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)end of week thing
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the honest answer is that most of us are running protocols nobody has ever studied
appetite returning at the end of the week is extremely common and is not the dose failing
the ladder in the trials is a starting point, not a schedule you owe anyone
the people who do best here are almost always the ones going slowest
update on the earlier thing whats the smallest step anyone has managed between doses