slightly off topic but plateau versus set point is not answerable in under six months of data
#dosing-titration 2026-06-28
Sunday69 messages13 participantstimes are UTC
Highlights from this day
- sage_sources — the honest answer is that most of us are running protocols nobody has ever studied, we shall see if you are asking whether to go up, the fact you are asking usually… 11:21
- swirl_not_shake — is it normal for appetite to come back at the end of the week dose day drift is mostly harmless with a weekly compound, but pick a day and defend it 14:15
- swirl_not_shake — appetite returning at the end of the week is extremely common and is not the dose failing 14:16
- sage_sources — my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step 17:06
ok so you do not have to escalate at all. that is a real option that gets forgotten
anyone here split their weekly into two and would they do it again
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whats the longest anyone has stayed on one dose
i drifted from sunday to wednesday over a year and only noticed when i checked the log
steady state is 5 weeks
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if it "stopped working after four days" that is almost never pharmacokinetics, someone check my working
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)if you are asking whether to go up, the fact you are asking usually means not yet
the honest answer is that most of us are running protocols nobody has ever studied, we shall see
if you are asking whether to go up, the fact you are asking usually means not yet
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update question: did anyone who held for 18 months regret it
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New independent result logged — MKM, lot G-0641, purity 98.6% (Janoshik).
came down, no regrets
holding is not failing. most people here who lasted two years held at least one dose for months
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came down from a treatment dose to maintenance over about three months and it was uneventful
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
no trial for that
the people who do best here are almost always the ones going slowest, not advice obviously
split dosing has no trial behind it. people here do it and report on it, thats all
too early imo
thats noise
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
update on the earlier thing dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
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half life is a week
update from 12 months ago: held at the same dose the whole time and still losing slowly
the trials escalated on a fixed schedule because a trial has to. you are not a trial
the ladder in the trials is a starting point, not a schedule you owe anyone, i have it written down somewhere
[edited]how much does the last dose still matter 5 days later
whats a sensible maintenance dose after a year at treatment dose
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do you count from injection day or from when you actually felt it
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if i took it 4 days late do i shift the schedule or go back to the old day
whats your rule for when a side effect means hold rather than push
unrelated but i escalate on symptoms. if the current dose is still doing something i stay on it, i could be wrong
i went from 5 to 2.4 and honestly could not tell the difference in appetite
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
nobody here can tell you what dose to be on and the ones who try get corrected
do you escalate on the calendar or on how you feel
*PeptideMeter not the other one
has anyone gone up and then straight back down and been glad they tried
pick a day and stick to it
how long did you hold at 5 before you moved up
is it normal for appetite to come back at the end of the week
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
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appetite returning at the end of the week is extremely common and is not the dose failing
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small steps are better than big ones and the only reason people take big ones is impatience
anyone tracked whether a smaller more frequent dose changed their side effects
quick one a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
if the current dose is still working, going up is spending headroom you might want later
sorry to jump in if i hold at 10 indefinitely am i losing anything
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
thats anecdote
stepping back down on purpose is a completely reasonable move and this channel should say so more often, anyway
with a roughly seven day half-life you are near steady state after about five weeks at a dose
two weeks is nothing
my dose day has drifted 8 days later over 26 months, does it matter
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
not advice
thats normal
i hold for two months minimum before i decide a dose has stopped doing anything
is there a trial anywhere that studied twice weekly, or is it all anecdote
i have been at 1.7 for 9 months and honestly i have stopped wanting to move
i would hold
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
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n of 1, your mileage will differ
my titration ladder took 19 months to climb and i would do it slower again, i could be wrong
does a missed week reset anything or do you just carry on