Spun off from a message in #dosing-titration on 2025-06-28. 12 messages, 4 participants.
same weekly total, two schedules
WEEKLY: 2.0mg every 7 days
peak after dose ~ high
trough at day 7 ~ low
average over week = X
SPLIT: 1.0mg every 3.5 days
peak after dose lower
trough higher
average over week = X <- identical
nothing about total exposure changes. the only thing you
buy is a flatter line. if your problem is the trough, that
is exactly what you wanted. if your problem is the peak
(nausea after dosing), same answer, other end.
thats correct and its worth stressing the average being identical, because people talk about splitting as if it reduces the dose
i genuinely thought it did
very common belief. it does not. lower peak is not lower dose
the practical cost is two injections and twice the chance of a drawing error
and twice as many small volumes, which is the real problem
the drawing side of it
10mg vial in 2ml = 5mg/ml
weekly 2.0mg = 0.40ml = 40 units on a u100
split 1.0mg = 0.20ml = 20 units, twice
20 units is still readable. splitting a 0.25mg starter
dose is 0.05ml = 5 units, then half of that is 2.5 units.
at that point you are guessing, so dont split starter doses.
wait so 0.05ml is 0.5 units?
no, 5 units. 1 unit = 0.01ml
*5 units not 0.5, i shifted the decimal. ok that makes more sense
everyone does that once. its why we write the units out longhand in here
summary for the archive: splitting flattens the curve, changes nothing about total exposure, and stops being drawable at low doses. thread done