vialroom

#maintenance 2025-08-02

Saturday20 messages5 participantstimes are UTC
Highlights from this day
  • pharmac_pen — a 10mg vial at a 2mg maintenance dose is five weeks of doses, so my monthly cost roughly halved 19:41
  • night_pin — right so did anyone drop the dose for maintenance or just stay where they were 20:32
  • pooled_sample — whats your rule for when a fluctuation becomes a regain 20:57
  • meal_prep_mick — appetite returning is not the drug failing, it is the drug doing less because you are taking less of it cost did not drop at maintenance for me because i went to a… 21:43
NP

the maintenance conversation barely existed in here two years ago and now it is half the channel

PP

a 10mg vial at a 2mg maintenance dose is five weeks of doses, so my monthly cost roughly halved

m0  118.4
m1  113.9
m2  110.2
m3  108.8
m4  108.1  <- the stall
m5  105.0
m6  101.6
m7   99.2

protein went up during maintenance for me rather than down, which was completely counterintuitive

NP

food noise coming back at a lower dose settled again after about four weeks for me

🎉3
NP

the honest answer to is this forever is that nobody knows and the drug only works while you are taking it

NP

follow up did your maintenance dose end up higher or lower than you expected it to

i put 7 back on after stopping and then went back on it. it worked the same the second time round

right so did anyone drop the dose for maintenance or just stay where they were

Cited study
Continued Treatment with Tirzepatide for Maintenance of Weight Reduction (SURMOUNT-4)
JAMA · 2024
Randomised withdrawal after a 36-week lead-in. Pairs with STEP 4.
PP

is a maintenance dose a real clinical thing or something we invented between us

ST

STEP 1 is the one where they stopped and it came back isnt it, has anyone read the actual numbers

PS

two or three kilos up and down is normal fluctuation. ten is a different conversation

MP

right so im holding at 5 for maintenance and wondering whether i should be lower

slightly off topic but how do you decide youre actually at maintenance rather than just stalled

🎉1

appetite returning is not the drug failing, it is the drug doing less because you are taking less of it
cost did not drop at maintenance for me because i went to a lower dose from the same vial and just used it slower

PP

how long did people stay at treatment dose after hitting goal

1