vialroom

#oral-glp1 2025-03-29

Saturday13 messages5 participantstimes are UTC
Highlights from this day
  • thirty_min_wait — roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose, still working it out 19:01
  • spreadsheet_stu — ok so i keep the tablet by the kettle so i take it before i think about food, anyway 19:37
  • cagri_curious — slightly off topic but PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses 19:41
  • meniscus_mel — anyone switched from injectable to oral and kept the same effect 19:56
  • vat_on_import — splitting a dose made the absorption problem worse rather than better in my own log i keep the tablet by the kettle so i take it before i think about food 22:21

roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose, still working it out

🧊1🤝4

while im here PIONEER or OASIS, which one was the higher dose oral

SS

ok so i keep the tablet by the kettle so i take it before i think about food, anyway

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slightly off topic but PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses

MM

whats the bioavailability actually like, i keep seeing about one percent

MM

the inconsistency is mostly technique and admitting that took me about a year, i have it written down somewhere

anyone switched from injectable to oral and kept the same effect

🙏1😂1🎉9
VO

oral was easier on my gut than injecting at what felt like a similar effect, which surprised me, we shall see

VO

splitting a dose made the absorption problem worse rather than better in my own log
i keep the tablet by the kettle so i take it before i think about food