went back to injecting
#oral-glp1 2025-08-08
Friday32 messages6 participantstimes are UTC
Highlights from this day
- coa_or_cope — the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them the non peptide agents dose daily without the water ritual, thats… 15:14
- assay_low_al — the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted oral was easier on my gut than injecting at what felt like a similar effect,… 15:46
- tarpit_tam — nobody should copy my morning routine, but the timer is the bit i would keep, take that with a pinch of salt 18:14
PIONEER or OASIS, which one was the higher dose oral
took mine with breakfast once by accident and that week was a write off
the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them
the non peptide agents dose daily without the water ritual, thats the practical difference
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the non peptide agents dose daily without the water ritual, thats the practical difference
thirty minutes, no cheating
is the plain water rule actually load bearing or is it a formality
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the fasting window is the difference between a dose and a very expensive tablet
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the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted
oral was easier on my gut than injecting at what felt like a similar effect, which surprised me
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SNAC does the work
*VendorInvestigate not the other one
does SNAC do anything other than get it through the stomach
i do 6am with water and eat at 7, thats been my routine for 25 months
is the inconsistency people report about the drug or about how they take it
tea also does not count, in case anyone was hoping, i have it written down somewhere
ok so coffee is not plain water. i tried it for a month and my results got worse
anyone switched from injectable to oral and kept the same effect
follow up absorption is the variable, not the molecule. same tablet, different morning, different result
i keep the tablet by the kettle so i take it before i think about food
is the non peptide thing why orforglipron doesnt need the fasting rules
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i use it because needles are a genuine problem for me, not because i think its better, i think
nobody should copy my morning routine, but the timer is the bit i would keep, take that with a pinch of salt
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one percent is the number people quote and the spread around it is the actual story
ruined my breakfast
PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
genuine question did anyone get consistent results on the oral or is it always patchy
roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose
splitting a dose made the absorption problem worse rather than better in my own log
PIONEER not OASIS
OASIS ran under the same sort of fasting conditions, thats not the variable between the two
is orforglipron a peptide at all