i take mine at 6am, is 30 minutes really enough
#oral-glp1 2025-11-08
Saturday42 messages11 participantstimes are UTC
Highlights from this day
- two_labs_two_answers — i have never lied about it. i have simply never mentioned it 17:34
- tarpit_tam — 36 weeks, mid teens percent weight reduction at the higher doses. thats a phase 2 result and it was better than most people expected from a small molecule 17:37
- ferrous_ash — thats the most important sentence anybody has typed in this channel 18:13
- tarpit_tam — boring wins more often than impressive does 20:03
did anyone go back to injecting after trying oral
PIONEER not OASIS
absorption is the variable, not the molecule. same tablet, different morning, different result
peptidemeter-summary-e-2205.pdf
2 pages · 930 KB · not retained in the public archive
orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ
absorption is the variable, not the molecule. same tablet, different morning, different result
i was wrong about the water amount, i was using a sip and it needs a lot more than that
😂9🧪2
PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
big mg small dose
update on the earlier thing anyone tracking whether their oral results line up week to week
i said 5 months ago that my oral results were random, they got consistent once i fixed the water
transit-times.csv
433 rows · not retained in the public archive
went back to injecting
orforglipron is the one that keeps getting called a game changer. why
because it is not a peptide
its a small molecule GLP-1 receptor agonist. so it does not need SNAC, does not need a fasting window, and does not care about water
and it still hits the same receptor
same receptor, different binding chemistry. non peptide agonists sit differently but activate it
that is genuinely clever
🧠9
the no rules part is the whole story for adherence. everyone in this channel has broken the 30 minute rule and lied about it
i have never lied about it. i have simply never mentioned it
😂14
36 weeks, mid teens percent weight reduction at the higher doses. thats a phase 2 result and it was better than most people expected from a small molecule
and phase 3
the obesity phase 3 programme has reported and the results were broadly consistent with phase 2. i would rather people read it than take my summary
which is the correct instinct and also why we cite journal and year for everything in here
so is this better than the injection
on weight, no, not at present. the injectables and especially the dual and triple agonists are ahead on the mean
on the chance that a real person takes it correctly every day for three years, possibly by a mile
thats the most important sentence anybody has typed in this channel
💯12🎯5
manufacturing too. a small molecule scales completely differently to a synthesised peptide
right. peptide supply has been the bottleneck for years, and small molecules do not have that bottleneck
does anyone have hands on experience
not really, and be very careful. anything sold as orforglipron in the grey market right now deserves maximum suspicion
the analytical picture is different too. its not a peptide, so a standard peptide purity assay is the wrong test entirely
correct. you would want a small molecule method. sending it to a lab expecting a peptide COA gets you a meaningless number
that seems like an easy way to get scammed
it is exactly how people are being scammed. see #scam-watch, there are three write ups already
for reference the legitimate large scale peptide houses like Bachem Holding have never pretended to be a route to this. they make peptides
and the standing reminder — nothing in this channel is approved for you to take, and nobody here is telling you to take anything
afk 10
your point about taking it correctly for three years — is adherence really that bad on the injections
on the real world data, yes. a lot of people stop in the first year and the reasons are rarely the ones trials measure
back. and thats the whole argument for a boring pill with no rules
boring wins more often than impressive does
✅9