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#oral-glp1 2025-11-27

Thursday12 messages3 participantstimes are UTC
Highlights from this day
  • slow.taper — is there any point splitting an oral dose absorption is the variable, not the molecule. same tablet, different morning, different result 13:11
  • slow.taper — PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses 13:26
  • mira_pins — why is the oral dose in mg so much bigger than the injectable one 13:34
  • ghent_gradient — oral was easier on my gut than injecting at what felt like a similar effect, which surprised me 13:58
ST

is there any point splitting an oral dose
absorption is the variable, not the molecule. same tablet, different morning, different result

Cited study
Oral Semaglutide 50 mg in Adults with Overweight or Obesity (OASIS 1)
The Lancet · 2023
The high-dose oral. Absorption rules matter enormously here.
MP

the oral mg number is bigger because almost none of it gets in, thats the entire reason

anyone switched from injectable to oral and kept the same effect

coffee is not plain water. i tried it for a month and my results got worse

ST

PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses

MP

why is the oral dose in mg so much bigger than the injectable one

13
GG

oral was easier on my gut than injecting at what felt like a similar effect, which surprised me

i do 6am with water and eat at 7, thats been my routine for 15 months