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#oral-glp1 2025-11-29

Saturday19 messages5 participantstimes are UTC
Highlights from this day
  • taste_changed — sorry to jump in why does the same tablet do different things week to week 22:09
  • taste_changed — the oral mg number is bigger because almost none of it gets in, thats the entire reason 22:10
  • zed_zeroes_in — SNAC raises the local pH and protects it long enough to cross, thats its whole job, ill dig out the number 22:38
  • plus_sixteen — orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ 22:40
  • VialBot — Purity check: no report on file for lot H-2814. Nothing logged either way. 23:05

does taking it with any food at all just waste the dose

PS

i said 19 months ago that my oral results were random, they got consistent once i fixed the water

plain water only

sorry to jump in why does the same tablet do different things week to week

🧪11📉3

the oral mg number is bigger because almost none of it gets in, thats the entire reason

📉7
ZZ

SNAC raises the local pH and protects it long enough to cross, thats its whole job, ill dig out the number

PS

orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ

PS

lost 21kg over 10 months on oral, slower than my injectable stretch, i stuck with it anyway

ZZ

took 18 weeks before i saw anything on oral, roughly twice what the injection took me

coming back to this does the 30 minutes start from swallowing or from the water

is the plain water rule actually load bearing or is it a formality

follow up the non peptide orals are the interesting part of this channel now, not oral semaglutide

*VendorInvestigate not the other one

VB

Purity check: no report on file for lot H-2814. Nothing logged either way.