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#oral-glp1 2026-01-14
Wednesday17 messages6 participantstimes are UTC
Highlights from this day
- salt_bridge — orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ 14:25
- triple_ag_tom — genuine question did anyone get consistent results on the oral or is it always patchy 16:22
- triple_ag_tom — is the absorption variability why the oral doses look so high the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them 16:25
- kev_measures — is the non peptide thing why orforglipron doesnt need the fasting rules SNAC raises the local pH and protects it long enough to cross, thats its whole job 16:35
- lead_time_lars — i said 12 months ago that my oral results were random, they got consistent once i fixed the water 16:46
orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ
follow up does the 30 minutes start from swallowing or from the water
how strict is the 30 minute wait before food for people here
while im here does taking it with any food at all just waste the dose
anyone tracking whether their oral results line up week to week
did anyone go back to injecting after trying oral
genuine question did anyone get consistent results on the oral or is it always patchy
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is the absorption variability why the oral doses look so high
the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them
how much water exactly, is it a small sip or half a glass
is the non peptide thing why orforglipron doesnt need the fasting rules
SNAC raises the local pH and protects it long enough to cross, thats its whole job
does SNAC do anything other than get it through the stomach
mine was patchy too
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about one percent
i said 12 months ago that my oral results were random, they got consistent once i fixed the water
why is the oral dose in mg so much bigger than the injectable one