coming back to this orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ
#oral-glp1 2026-01-17
Saturday31 messages7 participantstimes are UTC
Highlights from this day
set a timer
is the absorption variability why the oral doses look so high
big mg small dose
nobody should copy my morning routine, but the timer is the bit i would keep
switched from injectable to oral, lost some of the effect, switched back after 25 months
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PIONEER not OASIS
anyone dosing oral because of a needle problem rather than preference
sorry to jump in my weekly log on oral is noisier than my injectable log ever was, same scales same mornings
absorption is the variable, not the molecule. same tablet, different morning, different result
is the inconsistency people report about the drug or about how they take it
i take mine at 6am, is 30 minutes really enough
how long before the oral did anything measurable for you
the oral mg number is bigger because almost none of it gets in, thats the entire reason
i do 6am with water and eat at 7, thats been my routine for 8 months
the fasting window is the difference between a dose and a very expensive tablet
genuine question why is the oral dose in mg so much bigger than the injectable one
[edited]ruined my breakfast
went back to injecting because the morning routine was too fragile around shift work
did OASIS use the same fasting conditions as the earlier work
SNAC does the work
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not a peptide
my oral results were inconsistent week to week and i eventually decided it was me, not the tablet, from memory
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whats the bioavailability actually like, i keep seeing about one percent
did anyone go back to injecting after trying oral
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about one percent
how strict is the 30 minute wait before food for people here
follow up roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose
did anyone get consistent results on the oral or is it always patchy
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*Medutest not the other one
fasted every morning
janoshik-b-0114.pdf
2 pages · 349 KB · not retained in the public archive
is there any point splitting an oral dose
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