whats the bioavailability actually like, i keep seeing about one percent
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#oral-glp1 2026-03-09
Monday23 messages8 participantstimes are UTC
Highlights from this day
- alt_ast_ali — the fasting window is the difference between a dose and a very expensive tablet 15:30
- seven_five_sweet — went back to injecting because the morning routine was too fragile around shift work 19:54
- triple_ag_tom — absorption is the variable, not the molecule. same tablet, different morning, different result 19:59
back after 1 months, has anything changed on the oral side
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is orforglipron a peptide at all
the fasting window is the difference between a dose and a very expensive tablet
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lost 7kg over 14 months on oral, slower than my injectable stretch, i stuck with it anyway, i have it written down somewhere
went back to injecting
splitting a dose made the absorption problem worse rather than better in my own log
set a timer
plain water only
quick one nobody should copy my morning routine, but the timer is the bit i would keep
OASIS ran under the same sort of fasting conditions, thats not the variable between the two
why does the same tablet do different things week to week
right so i said 7 months ago that my oral results were random, they got consistent once i fixed the water
*that should say weekly
PIONEER or OASIS, which one was the higher dose oral
the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them
about one percent
Reminder for triple_ag_tom: dose day is today. Set 5 days ago.
is the absorption variability why the oral doses look so high
thirty minutes, no cheating
went back to injecting because the morning routine was too fragile around shift work
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genuine question the non peptide orals are the interesting part of this channel now, not oral semaglutide
absorption is the variable, not the molecule. same tablet, different morning, different result
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