coming back to this i do 6am with water and eat at 7, thats been my routine for 24 months
#oral-glp1 2026-04-01
Wednesday30 messages7 participantstimes are UTC
Highlights from this day
- karl_fischer — i said 6 months ago that my oral results were random, they got consistent once i fixed the water 19:34
- verify_or_dont — i use it because needles are a genuine problem for me, not because i think its better 20:45
- stable_not_volatile — while im here whats the bioavailability actually like, i keep seeing about one percent 20:47
- stable_not_volatile — PIONEER or OASIS, which one was the higher dose oral 20:48
- verify_or_dont — why does the same tablet do different things week to week 21:20
i said 6 months ago that my oral results were random, they got consistent once i fixed the water
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did OASIS use the same fasting conditions as the earlier work
is the absorption variability why the oral doses look so high
the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them
absorption is the variable, not the molecule. same tablet, different morning, different result
ruined my breakfast
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anyone dosing oral because of a needle problem rather than preference
does the 30 minutes start from swallowing or from the water
big mg small dose
coa-a-2418.pdf
1 page · 208 KB · not retained in the public archive
does SNAC do anything other than get it through the stomach
anyone tracking whether their oral results line up week to week
fasted every morning
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how much water exactly, is it a small sip or half a glass
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took mine with breakfast once by accident and that week was a write off, ask me again in a month
one percent is the number people quote and the spread around it is the actual story
i was wrong about the water amount, i was using a sip and it needs a lot more than that
PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
the fasting window is the difference between a dose and a very expensive tablet
plain water only
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i use it because needles are a genuine problem for me, not because i think its better
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while im here whats the bioavailability actually like, i keep seeing about one percent
coa-b-0114.pdf
1 page · 470 KB · not retained in the public archive
PIONEER or OASIS, which one was the higher dose oral
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not a peptide
coffee doesnt count
update on the earlier thing lost 40kg over 2 months on oral, slower than my injectable stretch, i stuck with it anyway
is the inconsistency people report about the drug or about how they take it
is there any point splitting an oral dose
why does the same tablet do different things week to week
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about one percent
janoshik-d-0718.pdf
2 pages · 96 KB · not retained in the public archive