PIONEER not OASIS
#oral-glp1 2026-06-09
Tuesday27 messages9 participantstimes are UTC
Highlights from this day
- brisbane_bac — for the archive is the absorption variability why the oral doses look so high 21:30
- lisbon_lot — lost 14kg over 10 months on oral, slower than my injectable stretch, i stuck with it anyway, thats just me 21:42
- nausea_window — how long before the oral did anything measurable for you 21:53
- taper_tess — is the inconsistency people report about the drug or about how they take it 21:56
- protein_floor — the non peptide agents dose daily without the water ritual, thats the practical difference 22:58
plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly, we shall see
anyone tracking whether their oral results line up week to week
for the archive is the absorption variability why the oral doses look so high
🔥1📈8
coffee is not plain water. i tried it for a month and my results got worse
went back to injecting because the morning routine was too fragile around shift work
SNAC raises the local pH and protects it long enough to cross, thats its whole job
lost 14kg over 10 months on oral, slower than my injectable stretch, i stuck with it anyway, thats just me
does the 30 minutes start from swallowing or from the water
[edited]PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
how long before the oral did anything measurable for you
is the inconsistency people report about the drug or about how they take it
✅14📉18
the inconsistency is mostly technique and admitting that took me about a year
anyone switched from injectable to oral and kept the same effect
[edited]orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ
anyone dosing oral because of a needle problem rather than preference
did OASIS use the same fasting conditions as the earlier work
set a timer
why is the oral dose in mg so much bigger than the injectable one
[edited]how strict is the 30 minute wait before food for people here
did anyone go back to injecting after trying oral
does SNAC do anything other than get it through the stomach
the non peptide agents dose daily without the water ritual, thats the practical difference
🧊15
went back to injecting
my oral results were inconsistent week to week and i eventually decided it was me, not the tablet
i use it because needles are a genuine problem for me, not because i think its better
is orforglipron a peptide at all