not a peptide
#oral-glp1 2026-06-22
Monday39 messages9 participantstimes are UTC
Highlights from this day
- tare_weight — coffee is not plain water. i tried it for a month and my results got worse 21:13
- split_shipment — orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ the oral mg number is bigger because almost none of it gets in,… 21:59
- tare_weight — switched from injectable to oral, lost some of the effect, switched back after 6 months 22:22
- gorse_gains — is there any point splitting an oral dose 22:34
the fasting rule cost me my breakfast routine and thats the real reason people quit the oral
coffee is not plain water. i tried it for a month and my results got worse
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mine was patchy too
PIONEER not OASIS
my oral results were inconsistent week to week and i eventually decided it was me, not the tablet, someone check my working
splitting a dose made the absorption problem worse rather than better in my own log, thats just me
the oral mg number is bigger because almost none of it gets in, thats the entire reason
the fasting window is the difference between a dose and a very expensive tablet, your mileage will differ
set a timer
SNAC raises the local pH and protects it long enough to cross, thats its whole job
went back to injecting
does the 30 minutes start from swallowing or from the water
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Recon calculator: 5mg in 2ml = 8mg/ml.
ruined my breakfast
fasted every morning
took 26 weeks before i saw anything on oral, roughly twice what the injection took me
i take mine at 6am, is 30 minutes really enough
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orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ
the oral mg number is bigger because almost none of it gets in, thats the entire reason
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i said 5 months ago that my oral results were random, they got consistent once i fixed the water
is the non peptide thing why orforglipron doesnt need the fasting rules
thirty minutes, no cheating
is orforglipron a peptide at all
the non peptide agents dose daily without the water ritual, thats the practical difference
coffee is not plain water. i tried it for a month and my results got worse
switched from injectable to oral, lost some of the effect, switched back after 6 months
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nobody should copy my morning routine, but the timer is the bit i would keep
is there any point splitting an oral dose
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how strict is the 30 minute wait before food for people here
does coffee count as plain water, asking for obvious reasons
PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
anyone dosing oral because of a needle problem rather than preference
i use it because needles are a genuine problem for me, not because i think its better
i keep the tablet by the kettle so i take it before i think about food
sorry to jump in back after 7 months, has anything changed on the oral side
is the inconsistency people report about the drug or about how they take it
changed my mind on the plain water rule after reading how SNAC works, its not a formality
did anyone get consistent results on the oral or is it always patchy
whats the bioavailability actually like, i keep seeing about one percent
my oral results were inconsistent week to week and i eventually decided it was me, not the tablet
coming back to this does SNAC do anything other than get it through the stomach
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