splitting a dose made the absorption problem worse rather

oral peptide bioavailability is very low, which is exactly why the oral dose is so much larger than the injected one

is there any point splitting an oral dose

the fasted window is the reason people give up on this rather than any effect from the compound

plain water only

orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ, dry storage, not cold chain

same, did not get easier

lost 24kg over 25 months on oral, slower than my injectable stretch, i stuck with it anyway, not medical advice

switched to injectable, reporting PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses, coffee does not count

the milligram figure is bigger because almost none of it gets absorbed. that is absorption, not potency, more water is a deviation

protocol pedantry the non peptide agents dose daily without the water ritual, thats the practical difference, off protocol is off the map

the quiet in this channel is because the protocol filters people out, not because there is nothing to say

storage for orals is a dry, room temperature problem rather than a cold chain one, research use only, not approved for human use

quiet channel but the empty stomach protocol and the small water volume are part of how the absorption was studied. they are not folklore, coffee does not count