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#oral-glp1 2025-06-27
Friday24 messages4 participantstimes are UTC
Highlights from this day
- mhra_unlicensed — sorry to jump in is there any point splitting an oral dose 23:08
- evidence_or_not — did anyone go back to injecting after trying oral 23:22
- mhra_unlicensed — lost 9kg over 24 months on oral, slower than my injectable stretch, i stuck with it anyway switched from injectable to oral, lost some of the effect, switched back… 23:53
tea also does not count, in case anyone was hoping
follow up is the non peptide thing why orforglipron doesnt need the fasting rules
sorry to jump in is there any point splitting an oral dose
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went back to injecting
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the non peptide agents dose daily without the water ritual, thats the practical difference, ymmv
one percent is the number people quote and the spread around it is the actual story
plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly
does the 30 minutes start from swallowing or from the water
not a peptide
technique probably
did anyone go back to injecting after trying oral
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the inconsistency is mostly technique and admitting that took me about a year, for what its worth
coffee doesnt count
i was wrong about the water amount, i was using a sip and it needs a lot more than that
update on the earlier thing how strict is the 30 minute wait before food for people here
*Janoshik not the other one
plain water only
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for the archive the fasting rule cost me my breakfast routine and thats the real reason people quit the oral, anyway
slightly off topic but is orforglipron a peptide at all
SNAC raises the local pH and protects it long enough to cross, thats its whole job
ruined my breakfast
changed my mind on the plain water rule after reading how SNAC works, its not a formality
lost 9kg over 24 months on oral, slower than my injectable stretch, i stuck with it anyway
switched from injectable to oral, lost some of the effect, switched back after 15 months