#reconstitution 2025-11-06

Thursday19 messages6 participantstimes are UTC

Highlights from this day

verify_or_dont — right so one unit is 0.01ml. 100 units is 1ml. everything else in this channel follows from that 19:34
quiet_head_qi — if you draw up with a bigger pin and inject with a fresh one you lose a bit more to dead space 20:40
ida_injects — coming back to this the vacuum will pull it in. let it. fighting it is how you get a face full of aerosol 21:02
ida_injects — the powder is stuck to the stopper, do i care 21:20
quiet_head_qi — update on the earlier thing im getting bubbles in the barrel every single time, what am i doing wrong 21:43

verify_or_dont 19:20

label the date too. you will not remember which vial is which by week 6, still working it out

mid_week_mo 19:23

aim the diluent at the glass wall, not at the powder. it goes in gentler

vienna_vial 19:28

read it at eye level

verify_or_dont 19:34

right so one unit is 0.01ml. 100 units is 1ml. everything else in this channel follows from that

lot-log.csv

830 rows · not retained in the public archive

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mid_week_mo 19:36

why does everyone say 2ml specifically and not 1ml

quiet_head_qi 19:51

took me a year to stop over-diluting. the measurement error at 4 units is worse than the convenience

quiet_head_qi 20:10

i write the mg/ml on the vial with a sharpie the moment i reconstitute it

verify_or_dont 20:12

5mg in 2ml gives 2.5mg/ml, 0.25mg is 10 units. good for a starting dose

vienna_vial 20:32

lyophilised powder is far more robust than people think. it is the solution that is fragile

quiet_head_qi 20:40

if you draw up with a bigger pin and inject with a fresh one you lose a bit more to dead space

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ida_injects 21:02

coming back to this the vacuum will pull it in. let it. fighting it is how you get a face full of aerosol

verify_or_dont label the date too. you will not remember which vial is which by week 6, still working…

ida_injects 21:17

the last few units are a real loss. i accept it rather than tilting the vial and drawing air

the powder is stuck to the stopper, do i care

10mg vial
  + 1.0ml  -> 10.0 mg/ml   0.5mg =  5u   1mg = 10u
  + 2.0ml  ->  5.0 mg/ml   0.5mg = 10u   1mg = 20u
  + 2.5ml  ->  4.0 mg/ml   0.5mg = 12.5u (dont)
  + 5.0ml  ->  2.0 mg/ml   0.5mg = 25u   1mg = 50u

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a1c_lag 21:21

how much do i lose to dead space with a 30G pin

quiet_head_qi 21:37

quick one does benzyl alcohol matter if im finishing the vial in one go

mid_week_mo aim the diluent at the glass wall, not at the powder. it goes in gentler

ida_injects 21:39

update from 6 months ago: switched to a single concentration and have not miscalculated since

quiet_head_qi 21:43

update on the earlier thing im getting bubbles in the barrel every single time, what am i doing wrong

verify_or_dont 21:44

not sterile water

quiet_head_qi 21:49

weighing the vial before you reconstitute is the only way to catch an underfill