vialroom
Thread · #reconstitution · 2025-06-21

whats the actual shelf life once its in solution

Spun off from a message in #reconstitution on 2025-06-21. 14 messages, 4 participants.

The message this came from
  • vacuum_vic — whats the actual shelf life once its in solution and who told you that number 18:59
VO

i have never once regretted using a rounder number and a slightly bigger volume, from my notes not memory

U1

i stopped using 1ml because the maths landed on halves. 5ml puts everything on a whole number, n of 1 obviously

MO

lyophilised powder is far more robust than people think. it is the solution that is fragile, ask me again in a month

😂5
VO

benzyl alcohol is what makes it bacteriostatic. it is about 0.9% typically, still working it out

⚠️6🔥4
MO

give it 4 minutes at room temperature before you decide it has not dissolved

U1

result came back bacteriostatic water for anything multi-use. sterile water has no preservative in it at all, thats with a 30G pin

MO

a jewellery scale to 0.01g is enough to catch a 10% short fill and not enough to catch a 2% one, measure twice, draw once

VV

the vacuum in a lyophilised vial is real. hold the plunger or it will pull the whole thing in, that was a 10mg vial

MO

sanity check on a volume 5mg in 1ml is 5mg/ml, so 0.5mg is 10 units. cleanest small vial numbers there are, before it goes back in the fridge

MO

one more on dead space bac water with benzyl alcohol if the vial is going to be opened more than about six times, that is the whole trick really