the honest position is this has less human evidence behind it than anything else discussed here
#retatrutide 2025-09-26
Friday37 messages8 participantstimes are UTC
Highlights from this day
- VialBot — Assay note: QST lot D-0718 reported at 98.6% of label content. 01:43
- tallinn_taper — the heart rate thing is real enough that i mention it whenever someone asks about starting 01:45
- underfill_uma — sorry to jump in held at 10 for 24 months and it never plateaued for me, which i cant explain, thats one data point 03:14
- steady_state_sue — phase 2 was still trending at the end which is why the phase 3 readout matters more than usual 05:47
- VialBot — Verification log updated: HJ — evidence added, status unchanged. 05:53
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
settled by month three
how long before people saw the first change at 12
i log resting heart rate every morning because of this and its the one number i actually watch, n of 1 obviously
does the glucagon arm explain the heart rate or is that unrelated
is the phase 2 dosing anywhere near what people here run
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
while im here lost 28kg over 14 months at doses well under what the trials used
how slow is low and slow here, four weeks a step or longer
Assay note: QST lot D-0718 reported at 98.6% of label content.
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the heart rate thing is real enough that i mention it whenever someone asks about starting
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sat at 2 for 5 months rather than climbing and it kept working, so i never went up
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
anyone reconstituting 15 vials to 2 so the steps come out smaller
logging rhr daily
glucagon is the new bit
no long term data
sorry to jump in held at 10 for 24 months and it never plateaued for me, which i cant explain, thats one data point
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people insist on small steps because the side effects arrive faster than on the other two
is the glucagon arm what people mean by the energy expenditure thing
mine went up too
GI was about the same as tirzepatide for me, the difference was how fast it arrived
*Medutest not the other one
came off at 3 weeks because my resting rate stayed elevated and i didnt like it
why does everyone insist on smaller steps here than on the other two
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Recon calculator: 5mg in 2ml = 8mg/ml.
im at 10 and the appetite effect is stronger than i expected, normal
reconstituted the 5 vial to 8mg/ml specifically so i could take 10 without measuring crumbs
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
watching my heart rate
sorry to jump in anyone logging resting heart rate on this
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
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genuine question appetite suppression at 0.5 was stronger than my tirzepatide experience at a comparable point, your mileage will differ
Verification log updated: HJ — evidence added, status unchanged.
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
my resting rate went up 6 bpm in the first month and came back most of the way by month 3