the heart rate thing is real enough that i mention it whenever someone asks about starting
#retatrutide 2025-11-12
Wednesday42 messages11 participantstimes are UTC
Highlights from this day
- cagri_curious — sat at 15 for 9 months rather than climbing and it kept working, so i never went up 19:55
- ms_ms_mira — anyone stayed at 10 for months rather than climbing 20:09
- alcohol_hits — anyone compared their VendorInvestigate purity across two different HJ lots 20:21
- sulphur_burp — phase 2 was still trending at the end which is why the phase 3 readout matters more than usual 20:45
- sulphur_burp — PeptideMeter came back 98.1 on one lot and 99.4 on the next from the same KP, both fine 20:50
sat at 15 for 9 months rather than climbing and it kept working, so i never went up
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smaller steps here
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is the GI worse than tirzepatide or about the same
anyone stayed at 10 for months rather than climbing
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update on the earlier thing reconstituted the 20 vial to 2.5mg/ml specifically so i could take 5 without measuring crumbs
anyone compared their VendorInvestigate purity across two different HJ lots
the half life supports weekly dosing and thats what ive done from the start, take that with a pinch of salt
i log resting heart rate every morning because of this and its the one number i actually watch
follow up appetite suppression at 5 was stronger than my tirzepatide experience at a comparable point
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule, ill dig out the number
is the phase 2 dosing anywhere near what people here run
research use only
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
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mine went up too
is the glucagon arm what people mean by the energy expenditure thing
PeptideMeter came back 98.1 on one lot and 99.4 on the next from the same KP, both fine
how long before people saw the first change at 12
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
stepping in 2.5 increments instead of doubling is the only thing i would change if i started again
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i said 9 months ago that my heart rate had settled and it has stayed settled since
Batch lookup A-2418: 5 independent reports on file, earliest 2025-07-02.
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
blood pressure stayed flat for me while heart rate moved, which i didnt expect
anyone gone above 1.7 and what changed
back after 4 months, has anything actually been published since
no idea whether the heart rate settles for everyone, mine did and one log isnt data
triple agonist yeah
low and slow
settled by month three
GI was about the same as tirzepatide for me, the difference was how fast it arrived
right so people insist on small steps because the side effects arrive faster than on the other two
the half life supports weekly dosing and thats what ive done from the start
cant feel it honestly
watching my heart rate
research use only is on every vial and i treat it as exactly that, nobody here is prescribing, we shall see
no long term data
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
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the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
the purity spread across lots worries me more than the molecule does
phase 2 only
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held mine ages
blood pressure stayed flat for me while heart rate moved, which i didnt expect
glucagon is the new bit