low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom, i could be wrong
#retatrutide 2025-11-13
Thursday36 messages9 participantstimes are UTC
Highlights from this day
- reta_resting_hr — my resting rate went up 8 bpm in the first month and came back most of the way by month 3 21:09
- pinch_not_stretch — the purity spread across lots worries me more than the molecule does 21:21
- alt_ast_ali — appetite suppression at 12 was stronger than my tirzepatide experience at a comparable point 22:19
- no_chargeback — unrelated but the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial 23:13
- no_chargeback — there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists 23:16
how slow is low and slow here, four weeks a step or longer
held mine ages
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quick one TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
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research use only is on every vial and i treat it as exactly that, nobody here is prescribing
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cant feel it honestly
reta_resting_hrquick one TRIUMPH is the phase 3 programme, thats the name to search rather than the…
the half life supports weekly dosing and thats what ive done from the start
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
came off at 6 weeks because my resting rate stayed elevated and i didnt like it
mine went up too
is the glucagon arm what people mean by the energy expenditure thing
quick one no idea whether the heart rate settles for everyone, mine did and one log isnt data, for what its worth
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settled by month three
people insist on small steps because the side effects arrive faster than on the other two
sorry to jump in nobody should read my log as a plan, im recording what i did and thats all it is
research use only
triple agonist yeah
no long term data
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anyone gone above 0.25 and what changed
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
stopped for 26 months and restarted at half my old dose, the ramp was easier second time, we shall see
my resting rate went up 8 bpm in the first month and came back most of the way by month 3
transit-times.csv
481 rows · not retained in the public archive
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the purity spread across lots worries me more than the molecule does
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logging rhr daily
the heart rate thing is real enough that i mention it whenever someone asks about starting
glucagon is the new bit
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TRIUMPH is phase 3
how long before people saw the first change at 5
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i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
low and slow
[edited]smaller steps here
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
appetite suppression at 12 was stronger than my tirzepatide experience at a comparable point
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)whats a sensible starting point, im seeing everything from 0.5 to 2
[edited]unrelated but the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
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there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
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