did anyone come off because of the heart rate
[edited]#retatrutide 2025-12-08
Monday44 messages12 participantstimes are UTC
Highlights from this day
- thank_you_year_on — anyone logging resting heart rate on this 22:03
- reta_resting_hr — triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history 22:31
- bo_bloodwork — anyone tracking blood pressure alongside the heart rate low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom 22:34
anyone logging resting heart rate on this
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)😂5❤️4
stepping in 15 increments instead of doubling is the only thing i would change if i started again
update on the earlier thing triple agonist meaning GLP-1, GIP and glucagon, have i got that right
mine went up too
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
the honest position is this has less human evidence behind it than anything else discussed here
appetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
lost 43kg over 5 months at doses well under what the trials used, i think
no idea whether the heart rate settles for everyone, mine did and one log isnt data
the heart rate thing is real enough that i mention it whenever someone asks about starting
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
TRIUMPH is phase 3
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
🤝13
anyone tracking blood pressure alongside the heart rate
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
🧪17🧊2📈9
whats a sensible starting point, im seeing everything from 0.5 to 2
came off at 20 weeks because my resting rate stayed elevated and i didnt like it, i think
cant feel it honestly
held mine ages
triple agonist yeah
watching my heart rate
anyone stayed at 10 for months rather than climbing
held at 0.25 for 13 months and it never plateaued for me, which i cant explain
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
why does everyone insist on smaller steps here than on the other two
follow up stopped for 12 months and restarted at half my old dose, the ramp was easier second time, your mileage will differ
the half life supports weekly dosing and thats what ive done from the start
settled by month three
fridge-temps.csv
753 rows · not retained in the public archive
people insist on small steps because the side effects arrive faster than on the other two
follow up Janoshik came back 98.1 on one lot and 99.4 on the next from the same CPC, both fine
how slow is low and slow here, four weeks a step or longer
whats the half life like, is it weekly the same way
did the phase 2 result actually come in higher than the tirzepatide numbers
glucagon is the new bit
no long term data
smaller steps here
medutest-report-g-0641.pdf
3 pages · 631 KB · not retained in the public archive
phase 2 only
ok so sat at 1.7 for 2 months rather than climbing and it kept working, so i never went up
logging rhr daily
is the glucagon arm what people mean by the energy expenditure thing
held at 0.5 for 15 months and it never plateaued for me, which i cant explain, i have it written down somewhere
i log resting heart rate every morning because of this and its the one number i actually watch
GI was about the same as tirzepatide for me, the difference was how fast it arrived