vialroom

#retatrutide 2026-02-03

Tuesday16 messages4 participantstimes are UTC
Highlights from this day
  • unsolicited_dm — for the archive reconstituted the 15 vial to 2mg/ml specifically so i could take 10 without measuring crumbs 10:59
  • mcg_not_mg — coming back to this lost 40kg over 17 months at doses well under what the trials used 13:04
  • apnoea_down_two — did the phase 2 plateau or was it still moving at the end 13:22
  • unsolicited_dm — the heart rate thing is real enough that i mention it whenever someone asks about starting, ill dig out the number 13:23
MN

coming back to this is the phase 2 dosing anywhere near what people here run

UD

people insist on small steps because the side effects arrive faster than on the other two

for the archive reconstituted the 15 vial to 2mg/ml specifically so i could take 10 without measuring crumbs

[edited]

slightly off topic but is the glucagon arm what people mean by the energy expenditure thing

i said 5 months ago that my heart rate had settled and it has stayed settled since, happy to be corrected

UD

there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists

UD

i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps

how do people square the research use only framing with logging their own use

MN

coming back to this lost 40kg over 17 months at doses well under what the trials used

🤝7
LO

smaller steps here

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.
AD

did the phase 2 plateau or was it still moving at the end

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)
UD

the heart rate thing is real enough that i mention it whenever someone asks about starting, ill dig out the number