the heart rate thing is real enough that i mention it whenever someone asks about starting, happy to be corrected
#retatrutide 2026-02-14
Saturday46 messages9 participantstimes are UTC
Highlights from this day
- satiety_sig — GI was about the same as tirzepatide for me, the difference was how fast it arrived 14:01
- sol_sends — buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely 14:28
- retention_time — anyone compared their Medutest purity across two different SSA lots 15:29
- assay_low_al — the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial 16:32
stepping in 15 increments instead of doubling is the only thing i would change if i started again
glucagon is the new bit
anyone stayed at 1.7 for months rather than climbing
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the half life supports weekly dosing and thats what ive done from the start
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phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
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research use only is on every vial and i treat it as exactly that, nobody here is prescribing, n of 1 obviously
no long term data
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sorry to jump in i said 9 months ago that my heart rate had settled and it has stayed settled since
watching my heart rate
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
came off at 8 weeks because my resting rate stayed elevated and i didnt like it
GI was about the same as tirzepatide for me, the difference was how fast it arrived
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mine went up too
stopped for 12 months and restarted at half my old dose, the ramp was easier second time
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buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
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the purity spread across lots worries me more than the molecule does
coming back to this there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
phase 2 only
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does the energy expenditure claim show up as anything you can feel
appetite suppression at 10 was stronger than my tirzepatide experience at a comparable point
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whats a sensible starting point, im seeing everything from 0.5 to 2
i log resting heart rate every morning because of this and its the one number i actually watch
held mine ages
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
[edited]low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
came off at 13 weeks because my resting rate stayed elevated and i didnt like it
anyone compared their Medutest purity across two different SSA lots
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settled by month three
did the phase 2 result actually come in higher than the tirzepatide numbers
follow up is the GI worse than tirzepatide or about the same
TRIUMPH is phase 3
appetite suppression at 1 was stronger than my tirzepatide experience at a comparable point, still working it out
smaller steps here
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
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blood pressure stayed flat for me while heart rate moved, which i didnt expect
my resting rate went up 9 bpm in the first month and came back most of the way by month 6
genuine question im at 1.7 and the appetite effect is stronger than i expected, normal
[edited]cant feel it honestly
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quick one i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind, i think
nobody should read my log as a plan, im recording what i did and thats all it is
logging rhr daily
low and slow
is the glucagon arm what people mean by the energy expenditure thing
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people insist on small steps because the side effects arrive faster than on the other two
while im here back after 8 months, has anything actually been published since
is the phase 2 dosing anywhere near what people here run
[edited]*PeptideMeter not the other one